Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 252381..252909 | Replicon | chromosome |
| Accession | NZ_CP080238 | ||
| Organism | Vibrio sp. ED002 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | ITG12_RS01495 | Protein ID | WP_045382929.1 |
| Coordinates | 252381..252671 (-) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A347UR02 |
| Locus tag | ITG12_RS01500 | Protein ID | WP_005377003.1 |
| Coordinates | 252661..252909 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ITG12_RS01460 (ITG12_01405) | 248009..249379 | + | 1371 | WP_248873462.1 | P-loop NTPase fold protein | - |
| ITG12_RS01465 | 249875..250004 | + | 130 | Protein_285 | DUF3265 domain-containing protein | - |
| ITG12_RS01470 (ITG12_01410) | 250232..251035 | + | 804 | WP_248873464.1 | hypothetical protein | - |
| ITG12_RS01480 (ITG12_01420) | 251431..251709 | + | 279 | WP_038880373.1 | hypothetical protein | - |
| ITG12_RS01485 (ITG12_01425) | 251727..251816 | + | 90 | WP_075111250.1 | DUF3265 domain-containing protein | - |
| ITG12_RS01490 (ITG12_01430) | 252240..252362 | + | 123 | WP_248873465.1 | DUF3265 domain-containing protein | - |
| ITG12_RS01495 (ITG12_01435) | 252381..252671 | - | 291 | WP_045382929.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| ITG12_RS01500 (ITG12_01440) | 252661..252909 | - | 249 | WP_005377003.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| ITG12_RS01505 | 252966..253076 | + | 111 | WP_231570825.1 | DUF3265 domain-containing protein | - |
| ITG12_RS01510 (ITG12_01445) | 253131..253973 | + | 843 | WP_248873467.1 | hypothetical protein | - |
| ITG12_RS01515 (ITG12_01450) | 254515..254643 | + | 129 | WP_099098883.1 | DUF3265 domain-containing protein | - |
| ITG12_RS01520 | 255061..255190 | + | 130 | Protein_295 | DUF3265 domain-containing protein | - |
| ITG12_RS01525 (ITG12_01455) | 255219..255692 | + | 474 | WP_025638270.1 | GrpB family protein | - |
| ITG12_RS01530 (ITG12_01460) | 255707..255799 | + | 93 | WP_193784098.1 | DUF3265 domain-containing protein | - |
| ITG12_RS01535 (ITG12_01465) | 256224..256346 | + | 123 | WP_081635053.1 | DUF3265 domain-containing protein | - |
| ITG12_RS01540 (ITG12_01470) | 256867..256956 | + | 90 | WP_072829120.1 | DUF3265 domain-containing protein | - |
| ITG12_RS27690 (ITG12_01475) | 257299..257574 | + | 276 | Protein_300 | DUF6236 family protein | - |
| ITG12_RS27695 (ITG12_01480) | 257552..257824 | + | 273 | WP_038882065.1 | DUF6236 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 160161..277551 | 117390 | |
| - | inside | Integron | - | - | 184077..270640 | 86563 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11273.31 Da Isoelectric Point: 10.5932
>T211340 WP_045382929.1 NZ_CP080238:c252671-252381 [Vibrio sp. ED002]
MIYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD
MIYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD
Download Length: 291 bp
>T211340 NZ_CP104846:c1456094-1455876 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9079.37 Da Isoelectric Point: 3.9610
>AT211340 WP_005377003.1 NZ_CP080238:c252909-252661 [Vibrio sp. ED002]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL
Download Length: 249 bp
>AT211340 NZ_CP104846:c1456494-1456120 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|