Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 252381..252909 Replicon chromosome
Accession NZ_CP080238
Organism Vibrio sp. ED002

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag ITG12_RS01495 Protein ID WP_045382929.1
Coordinates 252381..252671 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag ITG12_RS01500 Protein ID WP_005377003.1
Coordinates 252661..252909 (-) Length 83 a.a.

Genomic Context

ITG12_RS01460ITG12_RS01465ITG12_RS01470ITG12_RS01480ITG12_RS01485ITG12_RS01490ITG12_RS01505ITG12_RS01510ITG12_RS01515ITG12_RS01520ITG12_RS01525ITG12_RS01530ITG12_RS01535ITG12_RS01540ITG12_RS27690ITG12_RS27695ITG12_RS01495ITG12_RS01500
Location: 248009..249379 (1371 bp)
Type: Others
Protein ID: WP_248873462.1
Location: 249875..250004 (130 bp)
Type: Others
Protein ID: Protein_285
Location: 250232..251035 (804 bp)
Type: Others
Protein ID: WP_248873464.1
Location: 251431..251709 (279 bp)
Type: Others
Protein ID: WP_038880373.1
Location: 251727..251816 (90 bp)
Type: Others
Protein ID: WP_075111250.1
Location: 252240..252362 (123 bp)
Type: Others
Protein ID: WP_248873465.1
Location: 252966..253076 (111 bp)
Type: Others
Protein ID: WP_231570825.1
Location: 253131..253973 (843 bp)
Type: Others
Protein ID: WP_248873467.1
Location: 254515..254643 (129 bp)
Type: Others
Protein ID: WP_099098883.1
Location: 255061..255190 (130 bp)
Type: Others
Protein ID: Protein_295
Location: 255219..255692 (474 bp)
Type: Others
Protein ID: WP_025638270.1
Location: 255707..255799 (93 bp)
Type: Others
Protein ID: WP_193784098.1
Location: 256224..256346 (123 bp)
Type: Others
Protein ID: WP_081635053.1
Location: 256867..256956 (90 bp)
Type: Others
Protein ID: WP_072829120.1
Location: 257299..257574 (276 bp)
Type: Others
Protein ID: Protein_300
Location: 257552..257824 (273 bp)
Type: Others
Protein ID: WP_038882065.1
Location: 252381..252671 (291 bp)
Type: Toxin
Protein ID: WP_045382929.1
Location: 252661..252909 (249 bp)
Type: Antitoxin
Protein ID: WP_005377003.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ITG12_RS01460 (ITG12_01405)248009..249379+1371WP_248873462.1P-loop NTPase fold protein-
ITG12_RS01465249875..250004+130Protein_285DUF3265 domain-containing protein-
ITG12_RS01470 (ITG12_01410)250232..251035+804WP_248873464.1hypothetical protein-
ITG12_RS01480 (ITG12_01420)251431..251709+279WP_038880373.1hypothetical protein-
ITG12_RS01485 (ITG12_01425)251727..251816+90WP_075111250.1DUF3265 domain-containing protein-
ITG12_RS01490 (ITG12_01430)252240..252362+123WP_248873465.1DUF3265 domain-containing protein-
ITG12_RS01495 (ITG12_01435)252381..252671-291WP_045382929.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ITG12_RS01500 (ITG12_01440)252661..252909-249WP_005377003.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ITG12_RS01505252966..253076+111WP_231570825.1DUF3265 domain-containing protein-
ITG12_RS01510 (ITG12_01445)253131..253973+843WP_248873467.1hypothetical protein-
ITG12_RS01515 (ITG12_01450)254515..254643+129WP_099098883.1DUF3265 domain-containing protein-
ITG12_RS01520255061..255190+130Protein_295DUF3265 domain-containing protein-
ITG12_RS01525 (ITG12_01455)255219..255692+474WP_025638270.1GrpB family protein-
ITG12_RS01530 (ITG12_01460)255707..255799+93WP_193784098.1DUF3265 domain-containing protein-
ITG12_RS01535 (ITG12_01465)256224..256346+123WP_081635053.1DUF3265 domain-containing protein-
ITG12_RS01540 (ITG12_01470)256867..256956+90WP_072829120.1DUF3265 domain-containing protein-
ITG12_RS27690 (ITG12_01475)257299..257574+276Protein_300DUF6236 family protein-
ITG12_RS27695 (ITG12_01480)257552..257824+273WP_038882065.1DUF6236 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--160161..277551117390
-insideIntegron--184077..27064086563


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11273.31 Da        Isoelectric Point: 10.5932

>T211340 WP_045382929.1 NZ_CP080238:c252671-252381 [Vibrio sp. ED002]
MIYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T211340 NZ_CP104846:c1456094-1455876 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT211340 WP_005377003.1 NZ_CP080238:c252909-252661 [Vibrio sp. ED002]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT211340 NZ_CP104846:c1456494-1456120 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A347UR02

References