Detailed information of TA system TA021134

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1240505..1241036
• Replicon: chromosome
• Accession: NC_006512
• Organism: Idiomarina loihiensis L2TR

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q5QYX2
• Locus tag: IL_RS05950
• Protein ID: WP_011234412.1
• Coordinates: 1240505..1240792 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q5QTT1
• Locus tag: IL_RS05955
• Protein ID: WP_011234413.1
• Coordinates: 1240782..1241036 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IL_RS05935	1235640..1237259	-	1620	WP_011234409.1	ABC transporter permease subunit	-
IL_RS05940	1237238..1238305	-	1068	WP_011234410.1	ABC transporter substrate-binding protein	-
IL_RS05945	1238307..1240499	-	2193	WP_011234411.1	bifunctional TVP38/TMEM64 family protein/FAD-dependent oxidoreductase	-
IL_RS05950	1240505..1240792	-	288	WP_011234412.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IL_RS05955	1240782..1241036	-	255	WP_011234413.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IL_RS05960	1241099..1243423	-	2325	WP_011234414.1	TonB-dependent receptor	-
IL_RS05965	1243632..1244555	+	924	WP_011234415.1	AraC family transcriptional regulator	-
IL_RS05970	1244697..1245236	+	540	WP_011234416.1	carboxymuconolactone decarboxylase family protein	-
IL_RS05975	1245288..1245686	+	399	WP_011234417.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11276.32 Da
• Isoelectric Point: 11.0167

>T21134 WP_011234412.1 NC_006512:c1240792-1240505 [Idiomarina loihiensis L2TR]
MSYKLTFKRSAYKEWKKLNKDVQAQFKARLKQRLESPHVPASRLKGMDNCYKVKLRKLGYRLVYQVRDSELVVTVVALGK
RDKNRVYISAQKRLD

Nucleotide

• Length: 288 bp

>T21134 NC_006512:c1240792-1240505 [Idiomarina loihiensis L2TR]
ATGAGTTATAAGCTGACGTTTAAACGTTCAGCTTATAAAGAATGGAAAAAGTTGAACAAGGATGTTCAGGCGCAATTTAA
AGCCAGACTCAAGCAGAGGCTTGAATCACCTCATGTCCCGGCGTCTCGCTTAAAGGGAATGGATAACTGTTACAAAGTGA
AATTGCGAAAACTGGGTTATAGATTGGTTTATCAAGTAAGAGATTCCGAGCTTGTGGTTACGGTTGTAGCTTTAGGCAAA
CGTGATAAAAACAGAGTGTATATTAGCGCTCAGAAACGACTGGATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9655.95 Da
• Isoelectric Point: 4.4498

>AT21134 WP_011234413.1 NC_006512:c1241036-1240782 [Idiomarina loihiensis L2TR]
MKTVRPIYARNSTSISELKKNPMAVVEESHGEPVAVLNRNQPAFYCIPAATYEALMEELEDRDLLELVKKRQHEDEVEVN
IDEL

Nucleotide

• Length: 255 bp

>AT21134 NC_006512:c1241036-1240782 [Idiomarina loihiensis L2TR]
ATGAAAACGGTTAGACCCATTTATGCACGCAACTCAACTAGCATTAGTGAGTTGAAAAAGAACCCAATGGCGGTTGTTGA
AGAGAGTCACGGTGAGCCGGTGGCTGTACTGAATCGGAATCAGCCCGCATTTTATTGCATTCCGGCAGCAACCTATGAAG
CGTTGATGGAAGAGCTGGAAGATAGGGATTTACTGGAGTTAGTTAAAAAACGCCAGCATGAAGATGAAGTCGAGGTGAAC
ATCGATGAGTTATAA

Structures

Toxin

• AlphaFold DB: Q5QYX2

Antitoxin

• AlphaFold DB: Q5QTT1