Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 244393..244952 Replicon chromosome
Accession NZ_CP080238
Organism Vibrio sp. ED002

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag ITG12_RS01425 Protein ID WP_031849398.1
Coordinates 244393..244671 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag ITG12_RS01430 Protein ID WP_005398409.1
Coordinates 244668..244952 (-) Length 95 a.a.

Genomic Context

ITG12_RS01385ITG12_RS01390ITG12_RS01395ITG12_RS01400ITG12_RS01405ITG12_RS01410ITG12_RS01415ITG12_RS01420ITG12_RS01435ITG12_RS01440ITG12_RS01445ITG12_RS01450ITG12_RS01455ITG12_RS01460ITG12_RS01425ITG12_RS01430
Location: 240030..240119 (90 bp)
Type: Others
Protein ID: WP_248873977.1
Location: 240147..240755 (609 bp)
Type: Others
Protein ID: WP_248873453.1
Location: 240930..242450 (1521 bp)
Type: Others
Protein ID: WP_248873455.1
Location: 242480..242572 (93 bp)
Type: Others
Protein ID: WP_072866293.1
Location: 242602..243219 (618 bp)
Type: Others
Protein ID: WP_053051972.1
Location: 243240..243332 (93 bp)
Type: Others
Protein ID: WP_080338851.1
Location: 243367..244251 (885 bp)
Type: Others
Protein ID: WP_248873457.1
Location: 244248..244310 (63 bp)
Type: Others
Protein ID: Protein_276
Location: 245029..245120 (92 bp)
Type: Others
Protein ID: Protein_279
Location: 245148..245555 (408 bp)
Type: Others
Protein ID: WP_248873458.1
Location: 246114..246203 (90 bp)
Type: Others
Protein ID: WP_248873978.1
Location: 246229..246870 (642 bp)
Type: Others
Protein ID: WP_038882470.1
Location: 246976..247881 (906 bp)
Type: Others
Protein ID: WP_248873460.1
Location: 248009..249379 (1371 bp)
Type: Others
Protein ID: WP_248873462.1
Location: 244393..244671 (279 bp)
Type: Toxin
Protein ID: WP_031849398.1
Location: 244668..244952 (285 bp)
Type: Antitoxin
Protein ID: WP_005398409.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ITG12_RS01385 (ITG12_01335)240030..240119+90WP_248873977.1DUF3265 domain-containing protein-
ITG12_RS01390 (ITG12_01340)240147..240755+609WP_248873453.1hypothetical protein-
ITG12_RS01395 (ITG12_01345)240930..242450+1521WP_248873455.1hypothetical protein-
ITG12_RS01400 (ITG12_01350)242480..242572+93WP_072866293.1DUF3265 domain-containing protein-
ITG12_RS01405 (ITG12_01355)242602..243219+618WP_053051972.1LysE family translocator-
ITG12_RS01410 (ITG12_01360)243240..243332+93WP_080338851.1DUF3265 domain-containing protein-
ITG12_RS01415 (ITG12_01365)243367..244251+885WP_248873457.1bacteriophage abortive infection AbiH family protein-
ITG12_RS01420244248..244310+63Protein_276DUF3265 domain-containing protein-
ITG12_RS01425 (ITG12_01370)244393..244671-279WP_031849398.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
ITG12_RS01430 (ITG12_01375)244668..244952-285WP_005398409.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
ITG12_RS01435 (ITG12_01380)245029..245120+92Protein_279DUF3265 domain-containing protein-
ITG12_RS01440 (ITG12_01385)245148..245555+408WP_248873458.1SMI1/KNR4 family protein-
ITG12_RS01445 (ITG12_01390)246114..246203+90WP_248873978.1DUF3265 domain-containing protein-
ITG12_RS01450 (ITG12_01395)246229..246870+642WP_038882470.1hypothetical protein-
ITG12_RS01455 (ITG12_01400)246976..247881+906WP_248873460.1hypothetical protein-
ITG12_RS01460 (ITG12_01405)248009..249379+1371WP_248873462.1P-loop NTPase fold protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--160161..277551117390
-insideIntegron--184077..27064086563


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10921.66 Da        Isoelectric Point: 4.3430

>T211339 WP_031849398.1 NZ_CP080238:c244671-244393 [Vibrio sp. ED002]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPMD

Download         Length: 279 bp

>T211339 NZ_CP104846:1272267-1273187 [Escherichia coli]
ATGGATCTGCGTGATAGCTATGCCAGGCAGGTTAAACTGTTGATGGCCGCTCTGCCGCATGTGGCGAAGGAATCCTGTTT
CGCGTTGAAAGGCGGCACAGCAATCAATTTATTTGTGCAGGATTTCCCCCGTCTATCGGTGGATATCGATCTGGCGTATA
AGAGCTTTGCGGATCGCGATACCGATCTGGCGGCGATCAACGACGCTTTGAAGAGAATTACTGCATCGCTGAACGGCAGA
CCGGGGATCACCGCGATTCGGCAGGAAAATAAAGCGGATGAAAAGCGCATCATTGTGAATACCGCTGATGCAAAGATTAA
GATCGAGGTTAGCCCGGTCTGGCGCGGGCTGTTGTTGCCTCCGGCAGAAATGCCTGTGTGCGAACGTGTGGAAATGGAGT
ATGGCTTCACCACCATGAGTGTCGTCTCGCTGGCGGATCTTTATGGCGGTAAAATATGTGCTGCGCTTGATCGTCAGCAT
CCGCGCGATCTGTTTGATGTGTTGAATATGCTGGGGAGACCGGGCCTGACGCGCGAAATTTTTGACGGTTTTCTTTGTTA
TCTGGCAGGCCATCCCCGTCCCATTGCCGAGTTGCTGGCTTCAAACTGGGATACAGATCGGATTGCCACGTTATACGCTC
AGGAATTTTCGGGGATGACTCAGCAGGAAACGTCGCTGGAATCGCTTCTGTCAGTAACGACTTTGCTGCCGCAGGCGTTG
AAGTCACATTTTACGGATCTGGATCGCGAGTTCTTGCTCAGTTTTAAGCAAAACAGCCCTGACTGGTCGCGGTATCGCTA
TCCTGAAATTCAGCATCTTCCGGCTATTCGCTGGAAGCAACGCAATCTGGCGATGCTTAAAGATAAAAATCCGGCGAAGT
ATGTGGCGGCGGTGAATAAGCTAGAGAGGGTGCTGGAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT211339 WP_005398409.1 NZ_CP080238:c244952-244668 [Vibrio sp. ED002]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT211339 NZ_CP104846:1271498-1272280 [Escherichia coli]
TTGCCAAACTATCTAAACTGGTTGATGCAAAACACGCTACCCGGTCAGGTGCTGCTCCAGTCATGGCTTACCCGCAATGG
CGTAGATCGTAAGCTTTCTTATCTCTATGTTCAGAATGGCTGGCTCAGGCGCATCGCTCACGGTGTGTACTGCCGGACGG
GCCGTGAGCCGGATTGGGTAGACGCGGTTTACTGCCTTCAAACACAGTGGGAAAAGCCTGTTCGGGTGGCGGGGCTAACC
AGCCTTGCGCTTCAGGGCCATGCGCACTATACCGAACCGGGTAAGCCGCAGGTCTGGCTCGCGCTTCCGGCTTACGTCAA
ACTGCCGGGATGGTTTGCTGCCTTCGAACAATCAGCAACATTTATCACGCTGTATACATCGGGCCTTACCGTTGATGTCT
CGTCATTTACTACGGAACTGAAAATTGGCGACCGGCAGTTAGCAGGCAGTGCACCGGAACTGGCCGCGTATGAGATCGCC
TGCGGCGTTCCTTCGTTGATCTCGTTCGAACATGCCGATGCTCTGTTTCAGGGGGGGAATCTTCTCAGCCCACGCAAATT
GCAGGCACTGCTTCGCGCCAGTCATTCGATTAAAACCAACCGGGTGATGCTTTACCTTGCCCGGCGTAATGGACACCCTT
ATTTTCAGTATCTTGATCAAAGCGGTATAGAAACAGGTACGGGAAAGCGGCAAATCATACCTGGTGGCTGGCTGGAGCCG
GATTATCAAATTACTGTTCCCCGCACATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A347UR21

References