Detailed information of TA system TA211339

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 244393..244952
• Replicon: chromosome
• Accession: NZ_CP080238
• Organism: Vibrio sp. ED002

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ITG12_RS01425
• Protein ID: WP_031849398.1
• Coordinates: 244393..244671 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A347UR21
• Locus tag: ITG12_RS01430
• Protein ID: WP_005398409.1
• Coordinates: 244668..244952 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ITG12_RS01385 (ITG12_01335)	240030..240119	+	90	WP_248873977.1	DUF3265 domain-containing protein	-
ITG12_RS01390 (ITG12_01340)	240147..240755	+	609	WP_248873453.1	hypothetical protein	-
ITG12_RS01395 (ITG12_01345)	240930..242450	+	1521	WP_248873455.1	hypothetical protein	-
ITG12_RS01400 (ITG12_01350)	242480..242572	+	93	WP_072866293.1	DUF3265 domain-containing protein	-
ITG12_RS01405 (ITG12_01355)	242602..243219	+	618	WP_053051972.1	LysE family translocator	-
ITG12_RS01410 (ITG12_01360)	243240..243332	+	93	WP_080338851.1	DUF3265 domain-containing protein	-
ITG12_RS01415 (ITG12_01365)	243367..244251	+	885	WP_248873457.1	bacteriophage abortive infection AbiH family protein	-
ITG12_RS01420	244248..244310	+	63	Protein_276	DUF3265 domain-containing protein	-
ITG12_RS01425 (ITG12_01370)	244393..244671	-	279	WP_031849398.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
ITG12_RS01430 (ITG12_01375)	244668..244952	-	285	WP_005398409.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
ITG12_RS01435 (ITG12_01380)	245029..245120	+	92	Protein_279	DUF3265 domain-containing protein	-
ITG12_RS01440 (ITG12_01385)	245148..245555	+	408	WP_248873458.1	SMI1/KNR4 family protein	-
ITG12_RS01445 (ITG12_01390)	246114..246203	+	90	WP_248873978.1	DUF3265 domain-containing protein	-
ITG12_RS01450 (ITG12_01395)	246229..246870	+	642	WP_038882470.1	hypothetical protein	-
ITG12_RS01455 (ITG12_01400)	246976..247881	+	906	WP_248873460.1	hypothetical protein	-
ITG12_RS01460 (ITG12_01405)	248009..249379	+	1371	WP_248873462.1	P-loop NTPase fold protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	160161..277551	117390
	-	inside	Integron	-	-	184077..270640	86563

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-69)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10921.66 Da
• Isoelectric Point: 4.3430

>T211339 WP_031849398.1 NZ_CP080238:c244671-244393 [Vibrio sp. ED002]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPMD

Nucleotide

• Length: 279 bp

>T211339 NZ_CP104846:1272267-1273187 [Escherichia coli]
ATGGATCTGCGTGATAGCTATGCCAGGCAGGTTAAACTGTTGATGGCCGCTCTGCCGCATGTGGCGAAGGAATCCTGTTT
CGCGTTGAAAGGCGGCACAGCAATCAATTTATTTGTGCAGGATTTCCCCCGTCTATCGGTGGATATCGATCTGGCGTATA
AGAGCTTTGCGGATCGCGATACCGATCTGGCGGCGATCAACGACGCTTTGAAGAGAATTACTGCATCGCTGAACGGCAGA
CCGGGGATCACCGCGATTCGGCAGGAAAATAAAGCGGATGAAAAGCGCATCATTGTGAATACCGCTGATGCAAAGATTAA
GATCGAGGTTAGCCCGGTCTGGCGCGGGCTGTTGTTGCCTCCGGCAGAAATGCCTGTGTGCGAACGTGTGGAAATGGAGT
ATGGCTTCACCACCATGAGTGTCGTCTCGCTGGCGGATCTTTATGGCGGTAAAATATGTGCTGCGCTTGATCGTCAGCAT
CCGCGCGATCTGTTTGATGTGTTGAATATGCTGGGGAGACCGGGCCTGACGCGCGAAATTTTTGACGGTTTTCTTTGTTA
TCTGGCAGGCCATCCCCGTCCCATTGCCGAGTTGCTGGCTTCAAACTGGGATACAGATCGGATTGCCACGTTATACGCTC
AGGAATTTTCGGGGATGACTCAGCAGGAAACGTCGCTGGAATCGCTTCTGTCAGTAACGACTTTGCTGCCGCAGGCGTTG
AAGTCACATTTTACGGATCTGGATCGCGAGTTCTTGCTCAGTTTTAAGCAAAACAGCCCTGACTGGTCGCGGTATCGCTA
TCCTGAAATTCAGCATCTTCCGGCTATTCGCTGGAAGCAACGCAATCTGGCGATGCTTAAAGATAAAAATCCGGCGAAGT
ATGTGGCGGCGGTGAATAAGCTAGAGAGGGTGCTGGAGTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11069.40 Da
• Isoelectric Point: 9.2167

>AT211339 WP_005398409.1 NZ_CP080238:c244952-244668 [Vibrio sp. ED002]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT211339 NZ_CP104846:1271498-1272280 [Escherichia coli]
TTGCCAAACTATCTAAACTGGTTGATGCAAAACACGCTACCCGGTCAGGTGCTGCTCCAGTCATGGCTTACCCGCAATGG
CGTAGATCGTAAGCTTTCTTATCTCTATGTTCAGAATGGCTGGCTCAGGCGCATCGCTCACGGTGTGTACTGCCGGACGG
GCCGTGAGCCGGATTGGGTAGACGCGGTTTACTGCCTTCAAACACAGTGGGAAAAGCCTGTTCGGGTGGCGGGGCTAACC
AGCCTTGCGCTTCAGGGCCATGCGCACTATACCGAACCGGGTAAGCCGCAGGTCTGGCTCGCGCTTCCGGCTTACGTCAA
ACTGCCGGGATGGTTTGCTGCCTTCGAACAATCAGCAACATTTATCACGCTGTATACATCGGGCCTTACCGTTGATGTCT
CGTCATTTACTACGGAACTGAAAATTGGCGACCGGCAGTTAGCAGGCAGTGCACCGGAACTGGCCGCGTATGAGATCGCC
TGCGGCGTTCCTTCGTTGATCTCGTTCGAACATGCCGATGCTCTGTTTCAGGGGGGGAATCTTCTCAGCCCACGCAAATT
GCAGGCACTGCTTCGCGCCAGTCATTCGATTAAAACCAACCGGGTGATGCTTTACCTTGCCCGGCGTAATGGACACCCTT
ATTTTCAGTATCTTGATCAAAGCGGTATAGAAACAGGTACGGGAAAGCGGCAAATCATACCTGGTGGCTGGCTGGAGCCG
GATTATCAAATTACTGTTCCCCGCACATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A347UR21