Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 167921..168449 | Replicon | chromosome |
| Accession | NZ_CP080238 | ||
| Organism | Vibrio sp. ED002 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A1E5D019 |
| Locus tag | ITG12_RS00770 | Protein ID | WP_017051697.1 |
| Coordinates | 167921..168211 (-) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | F9RG96 |
| Locus tag | ITG12_RS00775 | Protein ID | WP_009387502.1 |
| Coordinates | 168201..168449 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ITG12_RS00715 (ITG12_00715) | 162939..163298 | - | 360 | WP_172840928.1 | hypothetical protein | - |
| ITG12_RS00720 (ITG12_00720) | 163427..163516 | + | 90 | WP_248873966.1 | DUF3265 domain-containing protein | - |
| ITG12_RS00725 (ITG12_00725) | 164037..164126 | + | 90 | WP_248873967.1 | DUF3265 domain-containing protein | - |
| ITG12_RS00730 (ITG12_00730) | 164163..164744 | + | 582 | WP_248873343.1 | DJ-1/PfpI family protein | - |
| ITG12_RS00735 (ITG12_00735) | 164767..164859 | + | 93 | WP_248873344.1 | DUF3265 domain-containing protein | - |
| ITG12_RS00740 | 165278..165407 | + | 130 | Protein_143 | DUF3265 domain-containing protein | - |
| ITG12_RS00745 (ITG12_00740) | 165437..166303 | + | 867 | WP_248873346.1 | hypothetical protein | - |
| ITG12_RS00750 (ITG12_00745) | 166334..166423 | + | 90 | Protein_145 | DUF3265 domain-containing protein | - |
| ITG12_RS00755 | 166841..166970 | + | 130 | Protein_146 | DUF3265 domain-containing protein | - |
| ITG12_RS00760 (ITG12_00750) | 167077..167403 | + | 327 | WP_248873348.1 | hypothetical protein | - |
| ITG12_RS00765 (ITG12_00755) | 167412..167813 | + | 402 | WP_248873350.1 | Rap1a/Tai family immunity protein | - |
| ITG12_RS00770 (ITG12_00760) | 167921..168211 | - | 291 | WP_017051697.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| ITG12_RS00775 (ITG12_00765) | 168201..168449 | - | 249 | WP_009387502.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| ITG12_RS00780 (ITG12_00770) | 169154..170035 | + | 882 | WP_248873352.1 | hypothetical protein | - |
| ITG12_RS00785 (ITG12_00775) | 170053..170142 | + | 90 | WP_248873968.1 | DUF3265 domain-containing protein | - |
| ITG12_RS00790 (ITG12_00780) | 170988..171128 | + | 141 | Protein_153 | DUF3265 domain-containing protein | - |
| ITG12_RS00795 (ITG12_00785) | 171158..172060 | + | 903 | WP_248873354.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 160161..277551 | 117390 | |
| - | inside | Integron | - | - | 160681..180811 | 20130 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11131.06 Da Isoelectric Point: 10.7148
>T211338 WP_017051697.1 NZ_CP080238:c168211-167921 [Vibrio sp. ED002]
MTYNLEFKSSALKEWKKLGATLQQQFKKKLIERLANPHVPASKLSGADNMYKIKLRQSGYRLVYKVQDDIVIVTVLAVGK
RERSDVYRKAMTRLND
MTYNLEFKSSALKEWKKLGATLQQQFKKKLIERLANPHVPASKLSGADNMYKIKLRQSGYRLVYKVQDDIVIVTVLAVGK
RERSDVYRKAMTRLND
Download Length: 291 bp
>T211338 NZ_CP104846:c1027046-1026666 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG
Antitoxin
Download Length: 83 a.a. Molecular weight: 8884.19 Da Isoelectric Point: 4.0474
>AT211338 WP_009387502.1 NZ_CP080238:c168449-168201 [Vibrio sp. ED002]
MTARILADVAASITEFKANPMKVASSAYGDPVAVLNRNEPAFYCVPAAAYEMMMDKLEDIELLALAKERESEASISVSID
DL
MTARILADVAASITEFKANPMKVASSAYGDPVAVLNRNEPAFYCVPAAAYEMMMDKLEDIELLALAKERESEASISVSID
DL
Download Length: 249 bp
>AT211338 NZ_CP104846:c1027267-1027046 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1E5D019 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1E5D030 |