Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 167921..168449 Replicon chromosome
Accession NZ_CP080238
Organism Vibrio sp. ED002

Toxin (Protein)


Gene name relE Uniprot ID A0A1E5D019
Locus tag ITG12_RS00770 Protein ID WP_017051697.1
Coordinates 167921..168211 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F9RG96
Locus tag ITG12_RS00775 Protein ID WP_009387502.1
Coordinates 168201..168449 (-) Length 83 a.a.

Genomic Context

ITG12_RS00720ITG12_RS00725ITG12_RS00730ITG12_RS00735ITG12_RS00740ITG12_RS00745ITG12_RS00750ITG12_RS00755ITG12_RS00760ITG12_RS00765ITG12_RS00780ITG12_RS00785ITG12_RS00790ITG12_RS00795ITG12_RS00715ITG12_RS00770ITG12_RS00775
Location: 163427..163516 (90 bp)
Type: Others
Protein ID: WP_248873966.1
Location: 164037..164126 (90 bp)
Type: Others
Protein ID: WP_248873967.1
Location: 164163..164744 (582 bp)
Type: Others
Protein ID: WP_248873343.1
Location: 164767..164859 (93 bp)
Type: Others
Protein ID: WP_248873344.1
Location: 165278..165407 (130 bp)
Type: Others
Protein ID: Protein_143
Location: 165437..166303 (867 bp)
Type: Others
Protein ID: WP_248873346.1
Location: 166334..166423 (90 bp)
Type: Others
Protein ID: Protein_145
Location: 166841..166970 (130 bp)
Type: Others
Protein ID: Protein_146
Location: 167077..167403 (327 bp)
Type: Others
Protein ID: WP_248873348.1
Location: 167412..167813 (402 bp)
Type: Others
Protein ID: WP_248873350.1
Location: 169154..170035 (882 bp)
Type: Others
Protein ID: WP_248873352.1
Location: 170053..170142 (90 bp)
Type: Others
Protein ID: WP_248873968.1
Location: 170988..171128 (141 bp)
Type: Others
Protein ID: Protein_153
Location: 171158..172060 (903 bp)
Type: Others
Protein ID: WP_248873354.1
Location: 162939..163298 (360 bp)
Type: Others
Protein ID: WP_172840928.1
Location: 167921..168211 (291 bp)
Type: Toxin
Protein ID: WP_017051697.1
Location: 168201..168449 (249 bp)
Type: Antitoxin
Protein ID: WP_009387502.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ITG12_RS00715 (ITG12_00715)162939..163298-360WP_172840928.1hypothetical protein-
ITG12_RS00720 (ITG12_00720)163427..163516+90WP_248873966.1DUF3265 domain-containing protein-
ITG12_RS00725 (ITG12_00725)164037..164126+90WP_248873967.1DUF3265 domain-containing protein-
ITG12_RS00730 (ITG12_00730)164163..164744+582WP_248873343.1DJ-1/PfpI family protein-
ITG12_RS00735 (ITG12_00735)164767..164859+93WP_248873344.1DUF3265 domain-containing protein-
ITG12_RS00740165278..165407+130Protein_143DUF3265 domain-containing protein-
ITG12_RS00745 (ITG12_00740)165437..166303+867WP_248873346.1hypothetical protein-
ITG12_RS00750 (ITG12_00745)166334..166423+90Protein_145DUF3265 domain-containing protein-
ITG12_RS00755166841..166970+130Protein_146DUF3265 domain-containing protein-
ITG12_RS00760 (ITG12_00750)167077..167403+327WP_248873348.1hypothetical protein-
ITG12_RS00765 (ITG12_00755)167412..167813+402WP_248873350.1Rap1a/Tai family immunity protein-
ITG12_RS00770 (ITG12_00760)167921..168211-291WP_017051697.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ITG12_RS00775 (ITG12_00765)168201..168449-249WP_009387502.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ITG12_RS00780 (ITG12_00770)169154..170035+882WP_248873352.1hypothetical protein-
ITG12_RS00785 (ITG12_00775)170053..170142+90WP_248873968.1DUF3265 domain-containing protein-
ITG12_RS00790 (ITG12_00780)170988..171128+141Protein_153DUF3265 domain-containing protein-
ITG12_RS00795 (ITG12_00785)171158..172060+903WP_248873354.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--160161..277551117390
-insideIntegron--160681..18081120130


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11131.06 Da        Isoelectric Point: 10.7148

>T211338 WP_017051697.1 NZ_CP080238:c168211-167921 [Vibrio sp. ED002]
MTYNLEFKSSALKEWKKLGATLQQQFKKKLIERLANPHVPASKLSGADNMYKIKLRQSGYRLVYKVQDDIVIVTVLAVGK
RERSDVYRKAMTRLND

Download         Length: 291 bp

>T211338 NZ_CP104846:c1027046-1026666 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8884.19 Da        Isoelectric Point: 4.0474

>AT211338 WP_009387502.1 NZ_CP080238:c168449-168201 [Vibrio sp. ED002]
MTARILADVAASITEFKANPMKVASSAYGDPVAVLNRNEPAFYCVPAAAYEMMMDKLEDIELLALAKERESEASISVSID
DL

Download         Length: 249 bp

>AT211338 NZ_CP104846:c1027267-1027046 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1E5D019

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1E5D030

References