Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | shpAB/BrnT-BrnA |
Location | 3940591..3941167 | Replicon | chromosome |
Accession | NZ_CP080235 | ||
Organism | Escherichia coli O139:H1 strain W13-16 |
Toxin (Protein)
Gene name | shpA | Uniprot ID | D3GXZ2 |
Locus tag | KZW92_RS19255 | Protein ID | WP_001297643.1 |
Coordinates | 3940591..3940878 (+) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | shpB | Uniprot ID | A0A080I7H7 |
Locus tag | KZW92_RS19260 | Protein ID | WP_000063160.1 |
Coordinates | 3940865..3941167 (+) | Length | 101 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KZW92_RS19235 (3936844) | 3936844..3938124 | - | 1281 | WP_001037400.1 | DUF445 domain-containing protein | - |
KZW92_RS19240 (3938165) | 3938165..3939397 | - | 1233 | WP_024186283.1 | multidrug efflux MFS transporter MdtM | - |
KZW92_RS19245 (3939543) | 3939543..3939638 | - | 96 | Protein_3773 | dienelactone hydrolase family protein | - |
KZW92_RS19250 (3939695) | 3939695..3940392 | + | 698 | Protein_3774 | IS1 family transposase | - |
KZW92_RS19255 (3940591) | 3940591..3940878 | + | 288 | WP_001297643.1 | BrnT family toxin | Toxin |
KZW92_RS19260 (3940865) | 3940865..3941167 | + | 303 | WP_000063160.1 | BrnA antitoxin family protein | Antitoxin |
KZW92_RS19265 (3941201) | 3941201..3942157 | - | 957 | WP_001297640.1 | GTPase | - |
KZW92_RS19270 (3942168) | 3942168..3942371 | - | 204 | WP_000467859.1 | YbdD/YjiX family protein | - |
KZW92_RS19275 (3942421) | 3942421..3944571 | - | 2151 | WP_001295524.1 | pyruvate/proton symporter BtsT | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11295.77 Da Isoelectric Point: 6.8821
>T211331 WP_001297643.1 NZ_CP080235:3940591-3940878 [Escherichia coli O139:H1]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG
Download Length: 288 bp
>T211331 NZ_CP104846:186212-186319 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11552.01 Da Isoelectric Point: 9.4646
>AT211331 WP_000063160.1 NZ_CP080235:3940865-3941167 [Escherichia coli O139:H1]
MSMVKHKRGTSSTLDVQHEAELKALTNKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK
MSMVKHKRGTSSTLDVQHEAELKALTNKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK
Download Length: 303 bp
>AT211331 NZ_CP104846:c186163-186098 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829GEV9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A080I7H7 |