Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2625087..2625613 | Replicon | chromosome |
| Accession | NZ_CP080233 | ||
| Organism | Escherichia coli O139:H1 strain P15-25 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | KZW90_RS12820 | Protein ID | WP_000323025.1 |
| Coordinates | 2625087..2625374 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | KZW90_RS12825 | Protein ID | WP_000534858.1 |
| Coordinates | 2625374..2625613 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZW90_RS12770 (2620111) | 2620111..2620326 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| KZW90_RS12775 (2620546) | 2620546..2620716 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| KZW90_RS12780 (2621080) | 2621080..2621295 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| KZW90_RS12785 (2621596) | 2621596..2621808 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| KZW90_RS12790 (2621863) | 2621863..2621952 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| KZW90_RS12795 (2622230) | 2622230..2622982 | - | 753 | WP_001047135.1 | antitermination protein | - |
| KZW90_RS12800 (2622996) | 2622996..2624045 | - | 1050 | WP_063085032.1 | DUF968 domain-containing protein | - |
| KZW90_RS12805 (2624047) | 2624047..2624325 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| KZW90_RS12810 (2624392) | 2624392..2624643 | - | 252 | WP_000980994.1 | protein Rem | - |
| KZW90_RS12815 (2624860) | 2624860..2625015 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| KZW90_RS12820 (2625087) | 2625087..2625374 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| KZW90_RS12825 (2625374) | 2625374..2625613 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| KZW90_RS12830 (2625638) | 2625638..2625943 | + | 306 | WP_001326990.1 | protein YdfV | - |
| KZW90_RS12835 (2626146) | 2626146..2626478 | + | 333 | WP_001301033.1 | FlxA-like family protein | - |
| KZW90_RS25115 (2626940) | 2626940..2627089 | - | 150 | WP_011443592.1 | protein YdfW | - |
| KZW90_RS12840 (2627210) | 2627210..2628232 | - | 1023 | Protein_2517 | ISNCY family transposase | - |
| KZW90_RS12845 (2629022) | 2629022..2629309 | - | 288 | Protein_2518 | hypothetical protein | - |
| KZW90_RS12850 (2629787) | 2629787..2630276 | - | 490 | Protein_2519 | class I SAM-dependent methyltransferase | - |
| KZW90_RS12855 (2630273) | 2630273..2630413 | - | 141 | Protein_2520 | DUF977 family protein | - |
| KZW90_RS12860 (2630411) | 2630411..2630596 | - | 186 | Protein_2521 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2608404..2642310 | 33906 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T211295 WP_000323025.1 NZ_CP080233:c2625374-2625087 [Escherichia coli O139:H1]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T211295 NZ_CP104836:c2941946-2941575 [Enterobacter cloacae]
GTGAATAATATGGCCGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTGTCGAAGCTGCGGATGCGATTGA
TCATGCCGCGTCACATCGAGCCATTAGCTTAATTACCTGGATGGAGGTGATGGTGGGCGCACGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTGATGGGCGCTTTCGAAATTATTGATGTGTCTCGGGATATCGCGGAAAGAAGCGTTTTACTGCGT
GAAAAGCATGGAATGAAACTGCCTGATGCCATCATTCTGGCCACAGCCCAGAGCAGAAAATGTCCGTTGATTTCTCGAAA
TACGAAAGATTTTTCGGGTATTGATGAGGTCGTTACGCCTTATCAACTGTAG
GTGAATAATATGGCCGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTGTCGAAGCTGCGGATGCGATTGA
TCATGCCGCGTCACATCGAGCCATTAGCTTAATTACCTGGATGGAGGTGATGGTGGGCGCACGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTGATGGGCGCTTTCGAAATTATTGATGTGTCTCGGGATATCGCGGAAAGAAGCGTTTTACTGCGT
GAAAAGCATGGAATGAAACTGCCTGATGCCATCATTCTGGCCACAGCCCAGAGCAGAAAATGTCCGTTGATTTCTCGAAA
TACGAAAGATTTTTCGGGTATTGATGAGGTCGTTACGCCTTATCAACTGTAG
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT211295 WP_000534858.1 NZ_CP080233:c2625613-2625374 [Escherichia coli O139:H1]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT211295 NZ_CP104836:c2942191-2941949 [Enterobacter cloacae]
ATGAGTGTTTTGGCGGAACTGGATATGGGCAGAATACTGATCGATTTACCTGATGACGTGATTCAACGGCTGGATAACCT
CAAGCAACTGCGAAATCAGCCGCGCGCTGAGCTGCTACGGGAGGCGATAGAGCTGTATCTCGACCAGCAGAGTTCGTCTG
TTATTCGCGCTGCGCTTGGCTTGTGGGGAGACAAGAAAGAAGACGGACTGGAGTATGAACGTAAGCTGCGTGAGGAATGG
TGA
ATGAGTGTTTTGGCGGAACTGGATATGGGCAGAATACTGATCGATTTACCTGATGACGTGATTCAACGGCTGGATAACCT
CAAGCAACTGCGAAATCAGCCGCGCGCTGAGCTGCTACGGGAGGCGATAGAGCTGTATCTCGACCAGCAGAGTTCGTCTG
TTATTCGCGCTGCGCTTGGCTTGTGGGGAGACAAGAAAGAAGACGGACTGGAGTATGAACGTAAGCTGCGTGAGGAATGG
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|