Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1770..2329 Replicon plasmid pP136-5
Accession NZ_CP080228
Organism Escherichia coli O141:H4 strain P13-6

Toxin (Protein)


Gene name relE Uniprot ID S1PMX5
Locus tag KZW89_RS27370 Protein ID WP_000421257.1
Coordinates 2054..2329 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C1J8K5
Locus tag KZW89_RS27365 Protein ID WP_001178089.1
Coordinates 1770..2054 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZW89_RS27360 (1) 1..858 + 858 WP_000130988.1 incFII family plasmid replication initiator RepA -
KZW89_RS27365 (1770) 1770..2054 + 285 WP_001178089.1 ribbon-helix-helix domain-containing protein Antitoxin
KZW89_RS27370 (2054) 2054..2329 + 276 WP_000421257.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZW89_RS27375 (2613) 2613..3800 - 1188 WP_000937591.1 IS91 family transposase -
KZW89_RS27380 (3800) 3800..4165 - 366 WP_000124086.1 hypothetical protein -
KZW89_RS27385 (4250) 4250..4444 + 195 Protein_6 carbohydrate transporter -
KZW89_RS27390 (4460) 4460..4588 + 129 Protein_7 glycosyltransferase family 1 protein -
KZW89_RS27395 (4661) 4661..4876 + 216 Protein_8 transposase -
KZW89_RS27400 (4966) 4966..6194 + 1229 WP_088895425.1 IS3-like element IS2 family transposase -
KZW89_RS27405 (6205) 6205..6574 + 370 Protein_10 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - hlyC / hlyA / hlyB / hlyD 1..86378 86378


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10749.45 Da        Isoelectric Point: 9.9324

>T211273 WP_000421257.1 NZ_CP080228:2054-2329 [Escherichia coli O141:H4]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T211273 NZ_CP104796:787507-787917 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10456.86 Da        Isoelectric Point: 5.6558

>AT211273 WP_001178089.1 NZ_CP080228:1770-2054 [Escherichia coli O141:H4]
IQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp

>AT211273 NZ_CP104796:787260-787526 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PMX5

Antitoxin

Source ID Structure
AlphaFold DB A0A731IHA8

References