Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1775..2328 Replicon plasmid pP136-3
Accession NZ_CP080226
Organism Escherichia coli O141:H4 strain P13-6

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag KZW89_RS26345 Protein ID WP_096217460.1
Coordinates 2044..2328 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag KZW89_RS26340 Protein ID WP_069192543.1
Coordinates 1775..2044 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZW89_RS26335 (1) 1..858 + 858 WP_042634321.1 incFII family plasmid replication initiator RepA -
KZW89_RS26340 (1775) 1775..2044 + 270 WP_069192543.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
KZW89_RS26345 (2044) 2044..2328 + 285 WP_096217460.1 type II toxin-antitoxin system toxin YacB Toxin
KZW89_RS26350 (2295) 2295..2573 + 279 Protein_3 IS66 family insertion sequence element accessory protein TnpB -
KZW89_RS26355 (2593) 2593..4164 + 1572 WP_062873784.1 IS66-like element ISCro1 family transposase -
KZW89_RS28985 (4199) 4199..4528 - 330 Protein_5 oxidoreductase -
KZW89_RS26360 (4528) 4528..4887 - 360 Protein_6 DDE-type integrase/transposase/recombinase -
KZW89_RS26365 (5070) 5070..6264 - 1195 Protein_7 IS91 family transposase -
KZW89_RS26370 (6264) 6264..6629 - 366 WP_000091308.1 hypothetical protein -
KZW89_RS26375 (6717) 6717..7323 - 607 Protein_9 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - estIa 1..82610 82610
- inside IScluster/Tn - estIa 2268..25722 23454


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.65 Da        Isoelectric Point: 9.4120

>T211271 WP_096217460.1 NZ_CP080226:2044-2328 [Escherichia coli O141:H4]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVTAWHQKFRTS

Download         Length: 285 bp

>T211271 NZ_CP104796:329936-330304 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGTATTACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10224.53 Da        Isoelectric Point: 6.4681

>AT211271 WP_069192543.1 NZ_CP080226:1775-2044 [Escherichia coli O141:H4]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVEQQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT211271 NZ_CP104796:329718-329939 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCTGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References