Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2925295..2925773 | Replicon | chromosome |
| Accession | NZ_CP080223 | ||
| Organism | Escherichia coli O141:H4 strain P13-6 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A7D8WGY6 |
| Locus tag | KZW89_RS14775 | Protein ID | WP_000936798.1 |
| Coordinates | 2925486..2925773 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | - |
| Locus tag | KZW89_RS14770 | Protein ID | WP_097330581.1 |
| Coordinates | 2925295..2925486 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZW89_RS14705 (2920344) | 2920344..2920562 | - | 219 | WP_219789374.1 | DUF4014 family protein | - |
| KZW89_RS14710 (2920564) | 2920564..2920779 | - | 216 | WP_047655285.1 | hypothetical protein | - |
| KZW89_RS14715 (2920780) | 2920780..2921139 | - | 360 | WP_219789375.1 | hypothetical protein | - |
| KZW89_RS14720 (2921136) | 2921136..2921312 | - | 177 | WP_000753067.1 | hypothetical protein | - |
| KZW89_RS14725 (2921305) | 2921305..2921487 | - | 183 | WP_024238437.1 | hypothetical protein | - |
| KZW89_RS14730 (2921581) | 2921581..2921937 | - | 357 | WP_097423158.1 | hypothetical protein | - |
| KZW89_RS14735 (2921915) | 2921915..2922379 | - | 465 | WP_023908487.1 | hypothetical protein | - |
| KZW89_RS14740 (2922372) | 2922372..2922671 | - | 300 | WP_001266141.1 | DUF4406 domain-containing protein | - |
| KZW89_RS14745 (2922668) | 2922668..2923063 | - | 396 | WP_096982553.1 | DUF977 family protein | - |
| KZW89_RS14750 (2923104) | 2923104..2924051 | - | 948 | WP_089569406.1 | helix-turn-helix domain-containing protein | - |
| KZW89_RS14755 (2924075) | 2924075..2924500 | - | 426 | WP_001605308.1 | toxin YdaT family protein | - |
| KZW89_RS14760 (2924484) | 2924484..2924756 | - | 273 | WP_097330580.1 | YdaS family helix-turn-helix protein | - |
| KZW89_RS14765 (2924866) | 2924866..2925267 | + | 402 | WP_001329851.1 | helix-turn-helix domain-containing protein | - |
| KZW89_RS14770 (2925295) | 2925295..2925486 | + | 192 | WP_097330581.1 | antitoxin | Antitoxin |
| KZW89_RS14775 (2925486) | 2925486..2925773 | + | 288 | WP_000936798.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KZW89_RS14780 (2926047) | 2926047..2926202 | + | 156 | WP_001678562.1 | DUF1391 family protein | - |
| KZW89_RS28845 (2926204) | 2926204..2926332 | + | 129 | WP_000344964.1 | protein YdfB | - |
| KZW89_RS28850 (2926344) | 2926344..2926616 | + | 273 | Protein_2904 | hypothetical protein | - |
| KZW89_RS14790 (2927670) | 2927670..2927867 | + | 198 | WP_000449166.1 | cell division inhibition protein DicB | - |
| KZW89_RS14795 (2927858) | 2927858..2928052 | + | 195 | WP_000538687.1 | DUF1482 family protein | - |
| KZW89_RS14800 (2928144) | 2928144..2930615 | + | 2472 | WP_120150362.1 | exonuclease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2880977..2939201 | 58224 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10899.83 Da Isoelectric Point: 10.1360
>T211259 WP_000936798.1 NZ_CP080223:2925486-2925773 [Escherichia coli O141:H4]
MLPILWLPSARDDLRQIVAYIAKENIPAARRLKIRIETSVLALSEHPYLYPPSDRVSGLREIVVHPNYIVLYRVAASSIE
IANIVHARRQFPFPI
MLPILWLPSARDDLRQIVAYIAKENIPAARRLKIRIETSVLALSEHPYLYPPSDRVSGLREIVVHPNYIVLYRVAASSIE
IANIVHARRQFPFPI
Download Length: 288 bp
>T211259 NZ_CP104788:4571930-4572103 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 64 a.a. Molecular weight: 7065.83 Da Isoelectric Point: 4.0270
>AT211259 WP_097330581.1 NZ_CP080223:2925295-2925486 [Escherichia coli O141:H4]
MSTALSPIVSEFETTEQENSYNEWLRAKVTSSLADPRPSIPHDEVMAEMENLIAQIAVTNRSE
MSTALSPIVSEFETTEQENSYNEWLRAKVTSSLADPRPSIPHDEVMAEMENLIAQIAVTNRSE
Download Length: 192 bp
>AT211259 NZ_CP104788:4571606-4571902 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|