Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2197116..2197630 Replicon chromosome
Accession NZ_CP080222
Organism Staphylococcus aureus strain NT_8

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag KZW87_RS11080 Protein ID WP_000581793.1
Coordinates 2197116..2197325 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KZW87_RS11085 Protein ID WP_000138932.1
Coordinates 2197337..2197630 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZW87_RS11060 (KZW87_11025) 2192625..2193983 - 1359 WP_000611482.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KZW87_RS11065 (KZW87_11030) 2193998..2195068 - 1071 WP_000159627.1 D-alanine--D-alanine ligase -
KZW87_RS11070 (KZW87_11035) 2195386..2196588 + 1203 WP_031590208.1 FtsW/RodA/SpoVE family cell cycle protein -
KZW87_RS11075 (KZW87_11040) 2196851..2196988 - 138 WP_000828354.1 Lmo0850 family protein -
KZW87_RS11080 (KZW87_11045) 2197116..2197325 - 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
KZW87_RS11085 (KZW87_11050) 2197337..2197630 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KZW87_RS11090 (KZW87_11055) 2197796..2199280 + 1485 WP_000571549.1 cardiolipin synthase -
KZW87_RS11095 (KZW87_11060) 2199308..2199955 + 648 WP_031590210.1 HD domain-containing protein -
KZW87_RS11100 (KZW87_11065) 2200569..2201441 - 873 WP_000725802.1 membrane protein insertase YidC -
KZW87_RS11105 (KZW87_11070) 2201527..2202168 - 642 WP_000483155.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T211237 WP_000581793.1 NZ_CP080222:c2197325-2197116 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T211237 NZ_CP104785:8736-283 [Acinetobacter baumannii]

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT211237 WP_000138932.1 NZ_CP080222:c2197630-2197337 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT211237 NZ_CP104785:270-584 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References