Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 1635063..1635866 | Replicon | chromosome |
| Accession | NZ_CP080222 | ||
| Organism | Staphylococcus aureus strain NT_8 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A2I7Y5B3 |
| Locus tag | KZW87_RS08135 | Protein ID | WP_000525004.1 |
| Coordinates | 1635405..1635866 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | KZW87_RS08130 | Protein ID | WP_001573842.1 |
| Coordinates | 1635063..1635392 (+) | Length | 110 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZW87_RS08060 (KZW87_08030) | 1630477..1630698 | - | 222 | WP_000815401.1 | DUF2483 family protein | - |
| KZW87_RS08065 (KZW87_08035) | 1630708..1630968 | - | 261 | WP_031584888.1 | DUF1108 family protein | - |
| KZW87_RS08070 (KZW87_08040) | 1630973..1631275 | - | 303 | WP_001608484.1 | DUF2482 family protein | - |
| KZW87_RS08075 (KZW87_08045) | 1631370..1631531 | - | 162 | WP_001285948.1 | DUF1270 domain-containing protein | - |
| KZW87_RS08080 (KZW87_08050) | 1631544..1631807 | - | 264 | WP_001124196.1 | helix-turn-helix domain-containing protein | - |
| KZW87_RS08085 (KZW87_08055) | 1631834..1632049 | - | 216 | WP_001097552.1 | hypothetical protein | - |
| KZW87_RS08090 (KZW87_08060) | 1632104..1632469 | + | 366 | WP_001128433.1 | hypothetical protein | - |
| KZW87_RS08095 (KZW87_08065) | 1632438..1632683 | - | 246 | WP_001025401.1 | DUF2829 domain-containing protein | - |
| KZW87_RS08100 (KZW87_08070) | 1632750..1633130 | + | 381 | WP_000773059.1 | DUF2513 domain-containing protein | - |
| KZW87_RS08105 (KZW87_08075) | 1633117..1633314 | - | 198 | WP_001148860.1 | hypothetical protein | - |
| KZW87_RS08110 | 1633384..1633674 | + | 291 | WP_094321613.1 | uracil-DNA glycosylase | - |
| KZW87_RS08115 (KZW87_08085) | 1633664..1633807 | - | 144 | WP_000939498.1 | hypothetical protein | - |
| KZW87_RS08120 (KZW87_08090) | 1633836..1634612 | - | 777 | WP_031914835.1 | Rha family transcriptional regulator | - |
| KZW87_RS08125 (KZW87_08095) | 1634626..1634871 | - | 246 | WP_094314651.1 | helix-turn-helix transcriptional regulator | - |
| KZW87_RS08130 (KZW87_08100) | 1635063..1635392 | + | 330 | WP_001573842.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| KZW87_RS08135 (KZW87_08105) | 1635405..1635866 | + | 462 | WP_000525004.1 | hypothetical protein | Toxin |
| KZW87_RS08140 (KZW87_08110) | 1635884..1636468 | + | 585 | WP_000825948.1 | hypothetical protein | - |
| KZW87_RS08145 (KZW87_08115) | 1636698..1636844 | + | 147 | WP_113342690.1 | hypothetical protein | - |
| KZW87_RS08150 (KZW87_08120) | 1636841..1637455 | - | 615 | WP_001636974.1 | phage protein | - |
| KZW87_RS08155 (KZW87_08125) | 1637581..1638786 | + | 1206 | WP_031585161.1 | tyrosine-type recombinase/integrase | - |
| KZW87_RS08160 (KZW87_08130) | 1638829..1640856 | - | 2028 | WP_031775750.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1592913..1651538 | 58625 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18074.46 Da Isoelectric Point: 4.6915
>T211232 WP_000525004.1 NZ_CP080222:1635405-1635866 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T211232 NZ_CP104766:c4746343-4746002 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGTGACGCTATGTCTGTCGTCTGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAAGGGATTC
AACTGGCAAGAACACTCCCCATATCTGCGGGCAGTTGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGCGCCGAAG
CCGTAAAAATGCTGTACGTTAA
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGTGACGCTATGTCTGTCGTCTGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAAGGGATTC
AACTGGCAAGAACACTCCCCATATCTGCGGGCAGTTGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGCGCCGAAG
CCGTAAAAATGCTGTACGTTAA
Antitoxin
Download Length: 110 a.a. Molecular weight: 12730.33 Da Isoelectric Point: 6.4836
>AT211232 WP_001573842.1 NZ_CP080222:1635063-1635392 [Staphylococcus aureus]
MRNNDEIITIIKTSMKEQNLSLSELARRVGVAKSAVSRYLNLTREFPLNRAEDFAKALSISTEYLLGFEKSEQKQEEPQH
RAAHLEGELTDDEWQRVLDYADYIRSKRK
MRNNDEIITIIKTSMKEQNLSLSELARRVGVAKSAVSRYLNLTREFPLNRAEDFAKALSISTEYLLGFEKSEQKQEEPQH
RAAHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 330 bp
>AT211232 NZ_CP104766:c4746705-4746364 [Klebsiella pneumoniae]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGACTTCACTATCTGGCTGACCGGGCCAGCATTACCGGTGAATTCAGCAACGCAGAATCTT
TGAAGTTGGATGAGGTATTCCCACATTTTATCAGCCAGATGGAGTCGATGCTGACTACTGGTGAAATGAATCCTCGCCAT
GCCCACTTTTTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGC
CGTTTACCCCACTCAACGTTAA
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGACTTCACTATCTGGCTGACCGGGCCAGCATTACCGGTGAATTCAGCAACGCAGAATCTT
TGAAGTTGGATGAGGTATTCCCACATTTTATCAGCCAGATGGAGTCGATGCTGACTACTGGTGAAATGAATCCTCGCCAT
GCCCACTTTTTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGC
CGTTTACCCCACTCAACGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|