21122

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 243902..244538 Replicon chromosome
Accession NC_006510
Organism Geobacillus kaustophilus HTA426

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag GK_RS01565 Protein ID WP_003253417.1
Coordinates 244188..244538 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID G8N2B5
Locus tag GK_RS01560 Protein ID WP_011229742.1
Coordinates 243902..244183 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GK_RS01540 240160..240777 - 618 WP_011229737.1 rhomboid family intramembrane serine protease -
GK_RS01545 240891..241280 + 390 WP_011229738.1 holo-ACP synthase -
GK_RS01550 241360..242372 + 1013 Protein_228 outer membrane lipoprotein carrier protein LolA -
GK_RS01555 242621..243775 + 1155 WP_011229741.1 alanine racemase -
GK_RS01560 243902..244183 + 282 WP_011229742.1 hypothetical protein Antitoxin
GK_RS01565 244188..244538 + 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
GK_RS01570 244804..246969 + 2166 WP_011229743.1 RNA-binding transcriptional accessory protein -
GK_RS18875 246988..247101 - 114 WP_013144046.1 cortex morphogenetic protein CmpA -
GK_RS01575 247191..247640 + 450 WP_011229744.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T21122 WP_003253417.1 NC_006510:244188-244538 [Geobacillus kaustophilus HTA426]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T21122 NC_006510:244188-244538 [Geobacillus kaustophilus HTA426]
TTGATTGTCAAACGTGGCGACGTGTATTTTGCGGACCTTTCCCCGGTTGTTGGCTCGGAGCAGGGCGGCGTGCGCCCCGT
GTTGGTGATCCAAAACGATATCGGCAATCGTTTTAGCCCGACGGTGATTGTCGCGGCGATTACGGCGCAAATCCAAAAAG
CGAAGCTGCCGACGCATGTCGAGATTGACGCGAAACGCTACGGGTTTGAACGCGATTCGGTCATTTTGCTTGAGCAAATT
CGCACGATCGACAAGCAACGGCTGACCGATAAAATCACTCATTTGGACGATGAAATGATGGATAAAGTCGATGAGGCGCT
GCAAATTAGCTTAGGACTGATCGACTTTTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10639.14 Da        Isoelectric Point: 7.2027

>AT21122 WP_011229742.1 NC_006510:243902-244183 [Geobacillus kaustophilus HTA426]
VSESGATAEIVVRLPQSLLTELDVLVKQENGNRNELIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFHAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT21122 NC_006510:243902-244183 [Geobacillus kaustophilus HTA426]
GTGTCGGAATCTGGCGCAACAGCGGAAATCGTCGTTCGTTTGCCGCAGTCGCTGCTGACAGAACTGGACGTGCTCGTAAA
GCAGGAAAACGGCAACCGCAATGAACTCATTTATCAAGCGACGAAAATGTACATTCGCGAGCGGAAGAAACGGCAAATTC
GCGAGGCGATGAGACGAGGCTACATGGAAATGGCGAAAATCAATTTATCTATCGCTTCTGAAGCGTTTCATGCTGAATAC
GAGGCCGACCACACCGTTGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9ETW5

References