Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3747934..3748769 Replicon chromosome
Accession NZ_CP080172
Organism Escherichia coli strain PK8566

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3K1A7W0
Locus tag KZY09_RS18225 Protein ID WP_021547705.1
Coordinates 3748392..3748769 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7W3AJG7
Locus tag KZY09_RS18220 Protein ID WP_001389198.1
Coordinates 3747934..3748302 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZY09_RS18185 (3743846) 3743846..3744526 + 681 WP_001282912.1 WYL domain-containing protein -
KZY09_RS18190 (3744677) 3744677..3745354 + 678 WP_001097567.1 hypothetical protein -
KZY09_RS18195 (3745360) 3745360..3745593 + 234 WP_001278282.1 DUF905 family protein -
KZY09_RS18200 (3745683) 3745683..3746501 + 819 WP_021547707.1 DUF932 domain-containing protein -
KZY09_RS18205 (3746593) 3746593..3747078 + 486 WP_219795596.1 antirestriction protein -
KZY09_RS18210 (3747094) 3747094..3747570 + 477 WP_001186727.1 RadC family protein -
KZY09_RS18215 (3747633) 3747633..3747854 + 222 WP_000692345.1 DUF987 domain-containing protein -
KZY09_RS18220 (3747934) 3747934..3748302 + 369 WP_001389198.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KZY09_RS18225 (3748392) 3748392..3748769 + 378 WP_021547705.1 TA system toxin CbtA family protein Toxin
KZY09_RS18230 (3748766) 3748766..3749254 + 489 WP_000761678.1 DUF5983 family protein -
KZY09_RS18235 (3749266) 3749266..3749463 + 198 WP_000839239.1 DUF957 domain-containing protein -
KZY09_RS18240 (3749548) 3749548..3750414 + 867 WP_021547704.1 DUF4942 domain-containing protein -
KZY09_RS18245 (3750486) 3750486..3750749 + 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
KZY09_RS18250 (3750746) 3750746..3751072 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
KZY09_RS18255 (3751536) 3751536..3752801 + 1266 WP_053274535.1 integrase arm-type DNA-binding domain-containing protein -
KZY09_RS18260 (3752933) 3752933..3753630 + 698 WP_232379276.1 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3666410..3753630 87220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13992.02 Da        Isoelectric Point: 7.7293

>T211203 WP_021547705.1 NZ_CP080172:3748392-3748769 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACSCSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T211203 NZ_CP104757:197884-198159 [Pectobacterium aroidearum]
ATGCAGGGAAAAATAGCCAGTCTACGAAAAAAGCAGCGAGAAACGCTGAGCCAAATTTTCAAAACACCCGTGCTTTCAGG
TGTTAAATGGTCAAATGTTGAGTCACTCATCACTGCGTTAGGTGGTGAAATTAAGGACGGTAGCGGGTCACGGGTGCGAT
TTTTATTGAATGGGAGTATCGCCCGGTTCCATCGTCCTCACCCGTCACCGGATACTGATAAAGGCGCATTGGTTAACCTG
CGTGAATGGTTGGAAAGTATAGGAGTAAAACCATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13610.39 Da        Isoelectric Point: 6.3159

>AT211203 WP_001389198.1 NZ_CP080172:3747934-3748302 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT211203 NZ_CP104757:198156-198518 [Pectobacterium aroidearum]
ATGACTAAAGCACTTAACACACCAAATACGATGGTTGTTTCCGGCCAACCGGCCATTATCAGCTATGTACCGGAAATCGG
TATGTTTCGCGGTAAGTTTATTGGCTTATCTGGCTACTGTGATTTTGTCGCTGACAGTATTAATGGGCTGAGAAACGAGG
GCGAAATTTCGCTACGTGAATATCTGGAAGACTGTCAGGAAAATGGCATTGAACCTTACGAACGTGAAGAGAAGGTGAAA
ACGTTCACTCTCCGTTATCCTGAATCATTCGGAGAACGACTGACTATTGCGGCGGCTGAACGTCAAATTTCAGTGAATAC
GTTTATTGTCGAAACGCTTAATGAACGTATGAAACAGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3K1A7W0

Antitoxin

Source ID Structure
AlphaFold DB A0A7W3AJG7

References