Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/Phd-LOTUS_5_Limkain_b1
Location 95668..96389 Replicon plasmid pTT27
Accession NC_006462
Organism Thermus thermophilus HB8

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag TTH_RS10525 Protein ID WP_014630570.1
Coordinates 95668..95976 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag TTH_RS10530 Protein ID WP_164926125.1
Coordinates 95973..96389 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TTH_RS10505 92097..93266 + 1170 WP_011229191.1 cytochrome P450 -
TTH_RS10510 93263..93961 + 699 WP_011174499.1 lycopene cyclase domain-containing protein -
TTH_RS10515 93966..94643 + 678 WP_011174498.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
TTH_RS10520 94640..95662 + 1023 WP_011174497.1 glycosyltransferase -
TTH_RS10525 95668..95976 + 309 WP_014630570.1 type II toxin-antitoxin system Phd/YefM family antitoxin Toxin
TTH_RS10530 95973..96389 + 417 WP_164926125.1 type II toxin-antitoxin system VapC family toxin Antitoxin
TTH_RS10535 96487..98055 + 1569 WP_011229188.1 phytoene desaturase -
TTH_RS10540 98052..99050 + 999 WP_011229187.1 type 2 isopentenyl-diphosphate Delta-isomerase -
TTH_RS10545 99060..99452 + 393 WP_011174492.1 nucleotidyltransferase domain-containing protein -
TTH_RS10550 99483..100430 - 948 WP_011229186.1 DUF523 and DUF1722 domain-containing protein -
TTH_RS10555 100427..101215 - 789 WP_011229185.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..256992 256992


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(20-83)

Antitoxin

PIN domain

(3-129)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11640.40 Da        Isoelectric Point: 8.5043

>T21120 WP_014630570.1 NC_006462:95668-95976 [Thermus thermophilus HB8]
VASKLDRPVFSVYPEGVKAIWQLQEAKARFSEVVERALKGEPQLVLRRGKKAVVVLDWETYARLTGEEASVLEALRPPKT
LPNEEVEALFQRQKTGFREVDF

Download         Length: 309 bp

>T21120 NC_006462:95668-95976 [Thermus thermophilus HB8]
GTGGCCTCTAAACTAGACAGACCGGTCTTTTCCGTGTACCCTGAGGGGGTGAAGGCCATCTGGCAACTCCAAGAGGCCAA
AGCCCGCTTTTCCGAGGTGGTGGAGCGGGCCCTCAAGGGGGAGCCCCAGCTCGTCCTCCGGCGGGGTAAGAAGGCGGTGG
TGGTGCTGGACTGGGAGACCTACGCCCGGCTCACGGGGGAAGAGGCCTCGGTCCTCGAGGCCCTAAGACCCCCCAAGACC
CTCCCCAATGAGGAGGTGGAAGCCCTCTTCCAAAGGCAAAAGACGGGCTTCCGGGAGGTGGACTTCTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15271.85 Da        Isoelectric Point: 10.4393

>AT21120 WP_164926125.1 NC_006462:95973-96389 [Thermus thermophilus HB8]
MRYLLDTNVVSEAVKRRPHPKVVAFLRHLKVGEAYLSALTLGELVQGVARAPEARRAILSRWLSGLKASFSGRILPLDAE
VMELWGELTGNAMREGKPLSPLDAMLAATTLRHGLILATRNTEDFRHVPVPLVNPWEG

Download         Length: 417 bp

>AT21120 NC_006462:95973-96389 [Thermus thermophilus HB8]
CTGAGGTACCTGTTGGACACCAACGTGGTCTCCGAGGCCGTCAAGCGGCGGCCTCACCCCAAGGTGGTGGCCTTCCTGCG
CCACCTTAAAGTGGGGGAGGCGTACCTCTCCGCCCTCACCTTGGGCGAACTGGTCCAGGGGGTGGCCCGGGCCCCGGAAG
CCCGAAGGGCCATCCTCAGCCGATGGCTCTCGGGGCTGAAGGCGAGCTTCTCGGGGCGGATCCTTCCCCTAGACGCCGAG
GTGATGGAGCTCTGGGGCGAGCTCACCGGAAACGCCATGAGGGAGGGCAAGCCCCTCTCTCCCCTAGACGCCATGCTGGC
GGCCACGACCCTGCGGCACGGCCTGATCCTGGCCACCCGGAACACCGAGGACTTCCGCCACGTTCCCGTGCCCCTCGTGA
ACCCCTGGGAAGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References