Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 466164..466816 Replicon chromosome
Accession NC_006461
Organism Thermus thermophilus HB8

Toxin (Protein)


Gene name vapC Uniprot ID Q5SKZ2
Locus tag TTH_RS02615 Protein ID WP_011227982.1
Coordinates 466164..466556 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5SKZ1
Locus tag TTH_RS02620 Protein ID WP_011227983.1
Coordinates 466556..466816 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TTH_RS02590 462767..463156 + 390 WP_011227977.1 NADH-quinone oxidoreductase subunit 15 -
TTH_RS02595 463159..464256 - 1098 WP_011227978.1 radical SAM family heme chaperone HemW -
TTH_RS02600 464249..464647 - 399 WP_011227979.1 HEPN domain-containing protein -
TTH_RS02605 464637..464954 - 318 WP_011227980.1 nucleotidyltransferase domain-containing protein -
TTH_RS02610 464959..466179 - 1221 WP_011227981.1 glycerate kinase -
TTH_RS02615 466164..466556 - 393 WP_011227982.1 type II toxin-antitoxin system VapC family toxin Toxin
TTH_RS02620 466556..466816 - 261 WP_011227983.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
TTH_RS02625 466849..468105 - 1257 WP_011227984.1 glycolate oxidase subunit GlcF -
TTH_RS02630 468110..469153 - 1044 WP_011227985.1 FAD-binding protein -
TTH_RS02635 469140..470522 - 1383 WP_011227986.1 FAD-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-85)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14636.82 Da        Isoelectric Point: 6.8735

>T21119 WP_011227982.1 NC_006461:c466556-466164 [Thermus thermophilus HB8]
MVLDTSALLGILFREEGYEELLEQLRRTRPHKVAAPTLAEAGIVLGARLGFERVHLLFELLTELQAEIVPFTERHAREAI
SAYRRYGRGKHPAGLNFGDCLSYALARVEGEPLLYKGQGFDRTDLAWKPS

Download         Length: 393 bp

>T21119 NC_006461:c466556-466164 [Thermus thermophilus HB8]
ATGGTGCTGGACACCTCCGCCCTCCTGGGCATTCTCTTCCGGGAAGAAGGGTACGAGGAGCTTCTGGAGCAACTCCGGCG
CACCCGCCCCCACAAGGTGGCCGCGCCCACCCTGGCCGAAGCGGGGATCGTCCTGGGCGCCCGGCTGGGCTTTGAGCGGG
TGCATCTTCTCTTTGAACTCCTAACCGAGCTCCAGGCCGAGATCGTGCCCTTCACCGAAAGGCATGCCCGGGAGGCCATC
TCCGCTTACCGGCGCTACGGGCGGGGCAAGCACCCCGCCGGGCTCAACTTTGGGGACTGCCTGAGCTACGCCCTGGCCCG
GGTGGAGGGGGAACCCCTCCTCTACAAGGGCCAGGGCTTTGACCGGACGGACCTGGCGTGGAAGCCCTCCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10086.61 Da        Isoelectric Point: 5.0285

>AT21119 WP_011227983.1 NC_006461:c466816-466556 [Thermus thermophilus HB8]
MALTIRNKEVERLAEEVARLAGETKTEAVRKALEMRLRELQRKRSFDRVIRFLEEEVWPQIPPELLGKGLSKEEEEEILG
YGKEGY

Download         Length: 261 bp

>AT21119 NC_006461:c466816-466556 [Thermus thermophilus HB8]
ATGGCCCTCACCATTCGCAACAAGGAGGTGGAGCGCCTGGCGGAGGAGGTGGCCCGCCTCGCCGGAGAAACCAAGACGGA
GGCCGTAAGGAAGGCCCTGGAGATGCGCCTTAGGGAACTCCAGAGGAAGCGGAGCTTTGACCGGGTGATCCGCTTCCTGG
AGGAGGAGGTCTGGCCCCAGATCCCGCCGGAGCTTTTGGGGAAGGGGCTCTCCAAGGAAGAGGAGGAAGAAATCCTGGGG
TACGGCAAGGAGGGGTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q5SKZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A7R7YHV5

References