Detailed information of TA system TA211189

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2002060..2003648
• Replicon: chromosome
• Accession: NZ_CP080172
• Organism: Escherichia coli strain PK8566

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: U9XU38
• Locus tag: KZY09_RS09930
• Protein ID: WP_001125455.1
• Coordinates: 2002326..2003648 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KZY09_RS09925
• Protein ID: WP_001296726.1
• Coordinates: 2002060..2002326 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZY09_RS09925 (2002060)	2002060..2002326	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
KZY09_RS09930 (2002326)	2002326..2003648	+	1323	WP_001125455.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
KZY09_RS09935 (2003960)	2003960..2004168	+	209	Protein_1951	AraC family transcriptional regulator	-
KZY09_RS09945 (2005221)	2005221..2006081	+	861	WP_232379281.1	fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2002060..2013268	11208
	-	flank	IS/Tn	-	-	2004482..2004985	503

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-401)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49321.93 Da
• Isoelectric Point: 8.8753

>T211189 WP_001125455.1 NZ_CP080172:2002326-2003648 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Nucleotide

• Length: 1323 bp

>T211189 NZ_CP104745:c2297970-2297053 [Erwinia pyrifoliae]
ATGGATAAGCAATCACCTTATTATCGGCAAGTTGCGTTGCTGCTCAGCGCATTGCCTGTTGTGGCAGCAGAGCGATGCTT
TGCACTAAAAGGTGGAACGGCTATAAACTTGTTTGTCCGTGATTTTCCACGTTTATCGGTTGATATCGATTTGGCTTACG
TTTTGCTGGAAAGCAGAGATGTGGCATTGCCAAATGTTCGGGCTGCTTTGATGCGTATTGCTGAAATACTGCAACAACAG
GCTGGCATTTCGGCGGTGCTACAAACGAATCATTCTGATGAAATGCGCATTGTGGTTTCTTCTCAGGAGGCACAGATAAA
GATAGAAGTTTCGCCTGTTGCGCGAGGCACACTCTATCCCCCAGAAGAACGTGATATTGTTGAAGCGGTAGAGGACGAGT
TCGGTTTCGCTACTATTCAGGTTGTATCGCTTGCCGATCTCTATGGTGGCAAGCTTTGTGCTGCGCTTGACAGGCAACAT
CCCCGTGATTTTTATGACGTCAAAATGCTACTCGAAACGCAAGGCATTGATCGCCAGATCTTTAATGGTTTCATCACCTA
TCTATTGGGACACCAACGCCCATTATCAGAGGTGCTTAATCCCCGCTGGAAAGATATTTCTGAGCTATATGCGAATGAAT
TTAACGGAATGACATTCGATGCGGTTTCTCTGGAAGAACTCAATGCGATACCCAACTTAATGGTTACTGCTCTCAAAGCA
CAATTCACGCAGCAGGATTATGATTTTTTGATGTCTTTCAAAAGTGGTCAACCGGACTGGAGTCTGGCTCCTGAAGATCA
GATTCAGCATCTACCAGCGGTTAAGTGGAAGTTGCAAAATATTGGGTGCATACCAAAAGGTAAGCATATTCAGGCGTTGG
CGAAGCTTGAGGCTGTTCTTGCCGAGTGGATAAAGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT211189 WP_001296726.1 NZ_CP080172:2002060-2002326 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT211189 NZ_CP104745:c2298736-2297963 [Erwinia pyrifoliae]
ATGTCATCAAAACTAAACTGGCTTTTGCAGAACACTGCGCCTGGCTCCTTGGTATTACAGTCCTGGTTGACAAAAAATGG
TATTAGCCCTTCTTTAGCCAATAAGTATATGCATAGTGACTGGTTACAAAAGCTACGTGCCGGTGTATACGTGCGGAGTG
GGCGTGAACCTCAGTGGAACGATGCCGTCTTATGCCTGCAAAATCAGCTGGGGATTTCTGTGCATCTGGCGGGGCTTACC
AGCCTGACCTGGCAGGGACGCTCTCATTATCTTCACTTAACGCGCCAGGCAATTTGGCTTTACGTAGAAGACAAAGCTTC
GTTGCCAAAGTGGTTCAAAGAATTTCCCAATGTCGAGTGGCTTTTACTTTCTAATCAGAAGCTCAATATGAATGACGAAA
AGTATCTGACAGCGGTAGAAATTAAGGGTGAGCGGTTGAAAGCGAGTGTGCCGGAATTAGCTGCTTACGAGATTGCTAAT
GCAGTCCCTGGTTCGCTGTCATTTGAGCACGCTGCGGAGCTGTTTCAGGGGCTGGTAAACCTGAGTCCACGTAAAGTCGA
AGTGTTGTTGCAATCCAGTCGAGCAGTGAAAACTAACCGCCTTTACCTGTTTCTGGCCGATCATTATGCTCATGCATGGG
TTACGCGAATAGATAAAGCCAACATTGATTTAGGGGCCGGGAAACGGCAGATCGTATCTGGTGGCAAGCTGGATCTAAAA
TATCAGATCACTGTTCCAGCGAGTTTTGTTAGCAAAGGGATCTCACATGGATAA

Structures

Toxin

• AlphaFold DB: U9XU38