Detailed information of TA system TA021118

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1349928..1350456
• Replicon: chromosome
• Accession: NC_006371
• Organism: Photobacterium profundum SS9

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q6LI07
• Locus tag: PBPR_RS24470
• Protein ID: WP_011221261.1
• Coordinates: 1350166..1350456 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q6LI08
• Locus tag: PBPR_RS24465
• Protein ID: WP_011221260.1
• Coordinates: 1349928..1350176 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PBPR_RS24450	1345585..1347163	+	1579	Protein_1225	IS3-like element ISPpr7 family transposase	-
PBPR_RS24455	1347203..1347673	+	471	Protein_1226	transposase	-
PBPR_RS24460	1348085..1349209	-	1125	WP_011221259.1	ISAs1-like element ISPpr12 family transposase	-
PBPR_RS24465	1349928..1350176	+	249	WP_011221260.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
PBPR_RS24470	1350166..1350456	+	291	WP_011221261.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PBPR_RS24475	1351009..1352295	+	1287	WP_011218608.1	IS4-like element ISPpr4 family transposase	-
PBPR_RS24480	1353209..1353835	+	627	WP_011221263.1	hypothetical protein	-
PBPR_RS29930	1354299..1354472	+	174	WP_157134408.1	phage integrase N-terminal SAM-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	1340996..1352295	11299

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-72)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11150.02 Da
• Isoelectric Point: 10.6684

>T21118 WP_011221261.1 NC_006371:1350166-1350456 [Photobacterium profundum SS9]
MSYKLDFKKSALKEWKKLGATLREQFKKKLIERLENPHVPASKLSGADNMYKIKLRQSGYRLVYEVNDGVITVTVLAVGK
RERSEVYKNAMRRTDS

Nucleotide

• Length: 291 bp

>T21118 NC_006371:1350166-1350456 [Photobacterium profundum SS9]
ATGAGCTATAAGTTAGACTTCAAGAAATCAGCCCTAAAAGAGTGGAAAAAACTTGGTGCTACACTTCGTGAACAGTTTAA
AAAGAAGCTGATTGAGCGATTGGAAAACCCACATGTACCGGCTTCAAAACTGTCTGGAGCCGATAATATGTATAAAATCA
AACTACGACAATCTGGTTACCGCTTAGTTTATGAAGTAAACGATGGTGTCATCACTGTTACCGTTCTTGCTGTTGGGAAA
CGTGAACGAAGCGAAGTATACAAGAATGCCATGCGTAGAACTGATTCGTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9050.38 Da
• Isoelectric Point: 4.0078

>AT21118 WP_011221260.1 NC_006371:1349928-1350176 [Photobacterium profundum SS9]
MTARILADVAASITELKANPMKVVSSAYGEPVAVLNRNEPAFYCVPAEAYELLMDRLEDLELLAIAKERQDEPSITVDIN
EL

Nucleotide

• Length: 249 bp

>AT21118 NC_006371:1349928-1350176 [Photobacterium profundum SS9]
ATGACCGCACGTATCCTTGCTGATGTTGCTGCTAGCATTACAGAGCTTAAAGCTAACCCAATGAAAGTCGTATCAAGTGC
TTATGGTGAACCTGTTGCTGTATTGAATAGAAATGAACCTGCATTCTATTGTGTACCAGCTGAAGCCTACGAACTACTTA
TGGATCGTTTAGAAGATCTTGAACTGCTTGCAATTGCAAAAGAACGTCAAGATGAGCCAAGCATCACGGTAGATATCAAT
GAGCTATAA

Structures

Toxin

• AlphaFold DB: Q6LI07

Antitoxin

• AlphaFold DB: Q6LI08