Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 395389..395984 Replicon chromosome
Accession NZ_CP080172
Organism Escherichia coli strain PK8566

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag KZY09_RS01900 Protein ID WP_000239579.1
Coordinates 395634..395984 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag KZY09_RS01895 Protein ID WP_001223208.1
Coordinates 395389..395640 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZY09_RS01885 (391053) 391053..394832 + 3780 WP_000060901.1 autotransporter assembly complex protein TamB -
KZY09_RS01890 (394835) 394835..395176 + 342 WP_063100134.1 gamma-glutamylcyclotransferase -
KZY09_RS01895 (395389) 395389..395640 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
KZY09_RS01900 (395634) 395634..395984 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
KZY09_RS01905 (396064) 396064..396594 - 531 WP_000055072.1 inorganic diphosphatase -
KZY09_RS01910 (396904) 396904..397860 + 957 WP_105078038.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
KZY09_RS01915 (398170) 398170..399672 + 1503 WP_000205793.1 sugar ABC transporter ATP-binding protein -
KZY09_RS01920 (399686) 399686..400708 + 1023 WP_001339490.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T211179 WP_000239579.1 NZ_CP080172:395634-395984 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T211179 NZ_CP104733:c3115071-3114751 [Pectobacterium sp. F1-1]
ATGCAAACATCATCTGCAATCCCGCCACGGGAGGATAACCCCTGTGCGTCGCCTATAGCCGTCTGGCAGCAACTGCTTAC
CTACCTGCTGGAAAAACACTACGGTCTGACGCTGAACGACACACCGTTCTGTGAGGAAAATGTTATTCAGGAACATATTG
ATGCTGGCATCACGTTGCTCAATGCCATCAATTTTCTGGTGGAAAAATATGAACTGGTGCGTATAGATCGCAACGGCTTT
AGCTGGCAGAAGCAATCGCCGTTTCTCACTGCCGTTGATGTTCTCCGTGCCAGACGTGCTACCGGCTTGCTCAAAGCATA
A

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT211179 WP_001223208.1 NZ_CP080172:395389-395640 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT211179 NZ_CP104733:c3115476-3115141 [Pectobacterium sp. F1-1]
ATGTCATTATCAGATTCCCCGGAATGGGGACTAAAACGTGCCGTTACTCCGCAATTCGGAGCCAGGCTGGTTCAGGAAGG
TCACTCTCTTCATTATCTGGCAGATCGGGCCAGTGTTATCGGTGCGTTCAGCAAAACAGAAGCTCGTCATCTGGAACAGA
TCTTTCCTGAGTTGATTAAGCAGTTGGAACAGAAGCTACGCACGGGGGAACTGAATCCCCATAAACAAGGCTGCATCACG
CTGCATTGCAACGAATGGACCTGTGAAGCCGATACGCTGGGCAGTTTTGGCTACGTGTATATTGTTATTTATCCAATTTC
TGCTGCAACACAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References