Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 190464..191389 Replicon chromosome
Accession NZ_CP080172
Organism Escherichia coli strain PK8566

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag KZY09_RS00865 Protein ID WP_014640052.1
Coordinates 191003..191389 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag KZY09_RS00860 Protein ID WP_024174200.1
Coordinates 190464..190973 (+) Length 170 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZY09_RS00830 (185483) 185483..186091 + 609 WP_000646078.1 transcriptional repressor LexA -
KZY09_RS00835 (186164) 186164..187489 + 1326 WP_001298861.1 MATE family efflux transporter DinF -
KZY09_RS00840 (187605) 187605..187814 + 210 WP_001030593.1 CsbD family protein -
KZY09_RS00845 (187856) 187856..188371 - 516 WP_032270355.1 zinc uptake transcriptional repressor Zur -
KZY09_RS26145 (188689) 188689..188943 + 255 WP_105077971.1 protein YjbL -
KZY09_RS00850 (188967) 188967..189679 + 713 Protein_160 DUF2713 family protein -
KZY09_RS00855 (190043) 190043..190147 + 105 Protein_161 tRNA-dihydrouridine synthase -
KZY09_RS00860 (190464) 190464..190973 + 510 WP_024174200.1 Panacea domain-containing protein Antitoxin
KZY09_RS00865 (191003) 191003..191389 + 387 WP_014640052.1 hypothetical protein Toxin
KZY09_RS00870 (191429) 191429..191602 + 174 WP_000390072.1 hypothetical protein -
KZY09_RS00875 (191650) 191650..191931 - 282 WP_001093916.1 pyocin activator PrtN family protein -
KZY09_RS00880 (191968) 191968..192750 - 783 WP_047654657.1 hypothetical protein -
KZY09_RS00885 (192939) 192939..193763 - 825 WP_000081311.1 DUF2303 family protein -
KZY09_RS00890 (193829) 193829..194191 - 363 WP_000135680.1 protein YfdP -
KZY09_RS00895 (194878) 194878..195552 - 675 WP_000859461.1 LexA family transcriptional regulator -
KZY09_RS00900 (195643) 195643..195843 + 201 WP_000649477.1 YdaS family helix-turn-helix protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 185005..209080 24075


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(6-116)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T211177 WP_014640052.1 NZ_CP080172:191003-191389 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

>T211177 NZ_CP104733:c1480309-1479890 [Pectobacterium sp. F1-1]
ATGACAGATATCTTGCTCAACAAAAGCAGCACCATACAAAGATGCCTGCGTCGTATTCGTGAGGAATTCGATACTGAGGA
AGGGTTTCGTCAAAACTTCACCAAGCAAGATTCCGTCATACTTAACATACAGCGTGCCTGCGAAGCCGCTATTGATATCG
CTAATTATCTTATCCGTATCAAGCAGCTAGGCATACCACAAAGTAGCCGCGATAGCTTCGCGCTTCTTGCTGCAAAACAG
ATTATTACGATTGATCTCTCTGATAATTTGCAAAAAATGGTGGGATTAAGAAATATTGCCGTGCATGACTATCAGGCGCT
CAATCTGGATATTGTCATCCACGTTATTTCTCATCGTTTAAGCGACTTTGAACATTTTATCAAACAAATAGCCCGGTACA
GCGACAGCCAGCACCTTTAG

Antitoxin


Download         Length: 170 a.a.        Molecular weight: 19559.39 Da        Isoelectric Point: 5.3338

>AT211177 WP_024174200.1 NZ_CP080172:190464-190973 [Escherichia coli]
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Download         Length: 510 bp

>AT211177 NZ_CP104733:c1480689-1480306 [Pectobacterium sp. F1-1]
ATGTTCGATAAGATCGTTTTGACACTGAAAAAACAGATACCCGACATCAAAATTATTTATCTCTTTGGTTCTCAGGCTAC
AGGCAATGCCAGAGCGGACAGCGACATTGATATCGCCATCATGGCTACGAGAGCACTGGATCCCGTTGAACGTTGGGAGC
TATCTAATCAATTAGCAAAAGAAGTGGGTCATGACGTCGATCTTATCGATTTATTGCAGGCTTCAACGGTATTAAAAATG
GAGATCGTTCGTAACGGCAAGCTGCTTTATGATGCGGAAACAGCAGCGAGAGAATTTGAAATGACAACACTTTCGATGTA
CCAGCATCTGCAAAAAGAGCGTGCGGATATCATTCGTAGCTTTAATCAGGATCTAAAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References