Detailed information of TA system TA021117

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 1342953..1343485
• Replicon: chromosome
• Accession: NC_006371
• Organism: Photobacterium profundum SS9

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q6LI15
• Locus tag: PBPR_RS24430
• Protein ID: WP_011221254.1
• Coordinates: 1343192..1343485 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: PBPR_RS24425
• Protein ID: WP_041395188.1
• Coordinates: 1342953..1343192 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PBPR_RS24400	1338574..1339551	+	978	WP_041395831.1	IS30 family transposase	-
PBPR_RS30860	1339698..1339973	-	276	WP_011221249.1	hypothetical protein	-
PBPR_RS24410	1339974..1340642	-	669	WP_197535875.1	hypothetical protein	-
PBPR_RS24415	1340729..1341547	+	819	Protein_1219	site-specific integrase	-
PBPR_RS24420	1341544..1342571	+	1028	Protein_1220	transposase	-
PBPR_RS24425	1342953..1343192	+	240	WP_041395188.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
PBPR_RS24430	1343192..1343485	+	294	WP_011221254.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PBPR_RS24435	1343599..1344147	-	549	WP_041395190.1	hypothetical protein	-
PBPR_RS24440	1344212..1345529	-	1318	Protein_1224	IS66 family transposase	-
PBPR_RS24450	1345585..1347163	+	1579	Protein_1225	IS3-like element ISPpr7 family transposase	-
PBPR_RS24455	1347203..1347673	+	471	Protein_1226	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	1340996..1352295	11299

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Antitoxin ParD (1-77)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11539.22 Da
• Isoelectric Point: 9.8918

>T21117 WP_011221254.1 NC_006371:1343192-1343485 [Photobacterium profundum SS9]
MNHFIVTNKAKSDLIDIARYTQKNWGINRRNSYLKQFDDSFHSLAREPMIGICCEYIKAGYRKFPQGSHIIYYRQNESQS
IEIIRVLHKSMDVNRNI

Nucleotide

• Length: 294 bp

>T21117 NC_006371:1343192-1343485 [Photobacterium profundum SS9]
ATGAACCATTTTATAGTAACCAATAAAGCCAAATCAGACTTGATTGATATTGCTAGATATACTCAAAAAAATTGGGGTAT
CAATCGACGAAATAGTTACTTAAAACAATTTGATGACAGTTTCCATTCATTAGCTAGAGAACCAATGATCGGCATATGTT
GTGAGTACATAAAGGCTGGCTATAGAAAGTTTCCTCAGGGTAGCCATATAATCTACTATCGACAGAATGAATCTCAAAGC
ATTGAAATTATTAGAGTCCTGCATAAAAGCATGGATGTTAATCGGAACATTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8894.75 Da
• Isoelectric Point: 5.0079

>AT21117 WP_041395188.1 NC_006371:1342953-1343192 [Photobacterium profundum SS9]
MSKNTSVTLGSHFDQFISQQLKSGRYGSASEVVRAGLRSLEDSEMKLQHLRIMLNEGETSGNSNYSYQDLISELDQENH

Nucleotide

• Length: 240 bp

>AT21117 NC_006371:1342953-1343192 [Photobacterium profundum SS9]
ATGTCTAAAAACACAAGTGTAACTCTAGGCAGTCATTTTGATCAGTTCATTTCTCAACAATTGAAAAGTGGTCGATATGG
ATCTGCCAGCGAAGTTGTAAGAGCAGGATTAAGATCACTAGAAGATAGTGAAATGAAATTGCAACACTTAAGAATCATGC
TAAATGAAGGTGAAACCAGCGGAAACAGCAACTATTCATATCAAGATTTAATCTCTGAATTAGACCAAGAAAACCACTGA

Structures

Toxin

• AlphaFold DB: Q6LI15