Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4336395..4337013 Replicon chromosome
Accession NZ_CP080163
Organism Escherichia coli strain PK8275

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag KZY08_RS20865 Protein ID WP_001291435.1
Coordinates 4336795..4337013 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag KZY08_RS20860 Protein ID WP_000344800.1
Coordinates 4336395..4336769 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZY08_RS20850 (4331484) 4331484..4332677 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KZY08_RS20855 (4332700) 4332700..4335849 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
KZY08_RS20860 (4336395) 4336395..4336769 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
KZY08_RS20865 (4336795) 4336795..4337013 + 219 WP_001291435.1 HHA domain-containing protein Toxin
KZY08_RS20870 (4337185) 4337185..4337736 + 552 WP_000102559.1 maltose O-acetyltransferase -
KZY08_RS20875 (4337852) 4337852..4338322 + 471 WP_000136192.1 YlaC family protein -
KZY08_RS20880 (4338486) 4338486..4340036 + 1551 WP_001389864.1 cyclic-guanylate-specific phosphodiesterase PdeB -
KZY08_RS20885 (4340078) 4340078..4340431 - 354 WP_000878140.1 DUF1428 domain-containing protein -
KZY08_RS20895 (4340810) 4340810..4341121 + 312 WP_000409911.1 MGMT family protein -
KZY08_RS20900 (4341152) 4341152..4341724 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T211159 WP_001291435.1 NZ_CP080163:4336795-4337013 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T211159 NZ_CP104727:2038676-2039446 [Pseudomonas citronellolis]
ATGGCCCTCGACGTCGGCGCCGAACTGTGGCGCGAATGCCGGGGCGAGCAGGCCATCGCCCCGCTGCGGGGCAAGCTGGT
GCGCCTGGTGGAGAGCCAGGAGCAGGTCGCGACCCTGCAACTGGTGGATACCCTGGAGGAACAGGCCCTGCTGGAAGAGC
TGATCGAGACCAGCAAGCCGCACCTGCCGCCGTCCACCGAAACCCTGCACTACCTGCTCAAGACGCCGTTCCGCTACCCG
CCGCTGCGCTGGGGCTCGCGCTTCGGCCGCCGCCACGAACCCAGCCTGTTCTACGCCGCGTTGCGCCTGGAGACGGCCAT
GGCCGAGGCGGCCTATTACCGCTTCGTGCTCTGGGAGGGCATGGCCAGTCCGCCGCCCAGCGGGCGCATCCTTTCCGAGC
ACGCTTCCTTCGAGGCGCGTTTCCAGGTGCAACGGGGCATACGCCTGCAGGCGCCGCCCTTCGACAGCTATGCCGAGCGC
CTGCAGGACCCGCGGGACTACCGCCTGACCCAGGCGCTGGGCAGCGCCATGCGCGCTGCCGCGGTGGAGGCCTTCGAATA
CCGCTCGGCGCGCTGCCCGGAAGGTGGGCTGAATGCCGCGCTCTTCGTGCCTTCGGCCTTCGTCGACAAGCGCCCGCGCA
ATCTCATGCCCTGGCTGTGCGAGACCACCGCCGACTACGTGGCCTTCAAGCATGCCCAGGTGCCGGGGGCGCCGCGGCTG
TTCCCGCGCGCGGGATTCCTGGTCGAGGGCGACCTGCCGCACCCGGCGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT211159 WP_000344800.1 NZ_CP080163:4336395-4336769 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT211159 NZ_CP104727:2038307-2038675 [Pseudomonas citronellolis]
ATGAGCGCACTGATCCGGGAAACTCCGTCGGCCGATCTGGTCCTGGCCAAGGCGGTACTGGCTGCCCGTGAGCAACTGGG
CATGACGCAGCAGGAGCTGGCCGCCATCGTCGGCGTCGACCGCAGCGCGGTGAGCCGCTGGAAGAGCGGCGGCCTGCGGG
TGGGCAGCAAGACCGGCGAGCTGGCGCTGCTGCTGGTGCGGGTATACCGCGCGCTCTTCGCCCTGTTCGGCGGCAACCTG
GAGGACATGCGCCACTTCCTGCGCACCCCCAACCGCCACCTGAGCGGTGTGCCGCTGCAGCGGATGGAGCAGGTGCAGGG
CCTGGTGCAGGTGGTCGAGTACCTCGACGCCATCCGGGGCAAGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References