Detailed information of TA system TA021114

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 1940780..1941357
• Replicon: chromosome
• Accession: NC_006370
• Organism: Photobacterium profundum SS9

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q6LRH3
• Locus tag: PBPR_RS08620
• Protein ID: WP_011218415.1
• Coordinates: 1941058..1941357 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q6LRH4
• Locus tag: PBPR_RS08615
• Protein ID: WP_011218414.1
• Coordinates: 1940780..1941061 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PBPR_RS08590	1935780..1936463	-	684	WP_011218409.1	CidB/LrgB family autolysis modulator	-
PBPR_RS08595	1936463..1936801	-	339	WP_011218410.1	CidA/LrgA family protein	-
PBPR_RS08600	1936945..1937469	-	525	WP_011218411.1	hypothetical protein	-
PBPR_RS08605	1937769..1939193	-	1425	WP_011218412.1	exodeoxyribonuclease I	-
PBPR_RS08610	1939371..1940546	+	1176	WP_011218413.1	site-specific integrase	-
PBPR_RS08615	1940780..1941061	+	282	WP_011218414.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
PBPR_RS08620	1941058..1941357	+	300	WP_011218415.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PBPR_RS08625	1941598..1942650	-	1053	WP_011218074.1	IS91 family transposase	-
PBPR_RS08630	1942647..1943534	-	888	Protein_1683	site-specific integrase	-
PBPR_RS30635	1943534..1943725	+	192	WP_157134313.1	hypothetical protein	-
PBPR_RS08635	1944298..1944888	+	591	WP_172635954.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11329.13 Da
• Isoelectric Point: 5.1131

>T21114 WP_011218415.1 NC_006370:1941058-1941357 [Photobacterium profundum SS9]
MKVVWSPLALEKLGLAAEFISIDNPVAAEKWVNDIFDKAEAIGSMPEMGRMVPELSYGHYREIIFGHYRIIYKITTEVQI
LTVRNCRQLLTSDDITNKD

Nucleotide

• Length: 300 bp

>T21114 NC_006370:1941058-1941357 [Photobacterium profundum SS9]
ATGAAAGTTGTTTGGTCACCATTAGCTCTTGAGAAGTTGGGTCTGGCAGCAGAGTTTATCTCGATAGATAACCCTGTTGC
TGCGGAAAAATGGGTAAATGATATTTTCGATAAAGCTGAAGCTATTGGAAGTATGCCTGAGATGGGACGTATGGTTCCGG
AGCTGTCTTATGGTCATTATCGAGAGATCATTTTCGGTCATTACCGCATCATCTATAAAATCACGACAGAAGTGCAGATA
TTAACTGTTCGTAATTGTAGGCAGTTGCTTACTTCTGATGATATAACAAATAAGGATTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10459.93 Da
• Isoelectric Point: 5.8720

>AT21114 WP_011218414.1 NC_006370:1940780-1941061 [Photobacterium profundum SS9]
MRRIHLDQDIQPLSEFRAGVASFIRQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEIQSAESQLASGLGVSN
EDARSQVLGRIKR

Nucleotide

• Length: 282 bp

>AT21114 NC_006370:1940780-1941061 [Photobacterium profundum SS9]
ATGCGACGTATACATTTAGACCAAGATATCCAACCTCTATCTGAGTTTCGGGCCGGTGTAGCTTCATTCATTCGCCAAAT
CAACGAGACTCGTCGACCATTAGTGATCACCCAGCGTGGTAAGGGTGTTGCTGTTGTTCTTGATGTTGCTGAATACGAAG
CGATGCAGGAAAAAATTGAGTTACTTGAAGAAATTCAAAGTGCGGAGTCCCAATTGGCTAGCGGTCTAGGTGTGTCTAAT
GAAGATGCTCGTTCTCAAGTTCTAGGTCGTATCAAAAGATGA

Structures

Toxin

• AlphaFold DB: Q6LRH3

Antitoxin

• AlphaFold DB: Q6LRH4