Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4709679..4710477 Replicon chromosome
Accession NZ_CP080155
Organism Escherichia coli strain PK8261

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag KZY07_RS22765 Protein ID WP_000854735.1
Coordinates 4710100..4710477 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A067H947
Locus tag KZY07_RS22760 Protein ID WP_001285415.1
Coordinates 4709679..4710053 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZY07_RS22725 (4705610) 4705610..4706290 + 681 WP_001282919.1 WYL domain-containing protein -
KZY07_RS22730 (4706438) 4706438..4707115 + 678 WP_001097302.1 hypothetical protein -
KZY07_RS22735 (4707121) 4707121..4707354 + 234 WP_001278287.1 DUF905 family protein -
KZY07_RS22740 (4707444) 4707444..4708262 + 819 WP_001175148.1 DUF932 domain-containing protein -
KZY07_RS22745 (4708344) 4708344..4708823 + 480 WP_000844100.1 antirestriction protein -
KZY07_RS22750 (4708839) 4708839..4709315 + 477 WP_001366855.1 RadC family protein -
KZY07_RS22755 (4709378) 4709378..4709599 + 222 WP_000692309.1 DUF987 domain-containing protein -
KZY07_RS22760 (4709679) 4709679..4710053 + 375 WP_001285415.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KZY07_RS22765 (4710100) 4710100..4710477 + 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
KZY07_RS22770 (4710474) 4710474..4710962 + 489 WP_000761676.1 DUF5983 family protein -
KZY07_RS22775 (4710974) 4710974..4711171 + 198 WP_000839265.1 DUF957 domain-containing protein -
KZY07_RS22780 (4711256) 4711256..4712122 + 867 WP_032153714.1 DUF4942 domain-containing protein -
KZY07_RS22785 (4712194) 4712194..4712457 + 264 WP_025492088.1 type II toxin-antitoxin system ParD family antitoxin -
KZY07_RS22790 (4712454) 4712454..4712780 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
KZY07_RS22795 (4713663) 4713663..4715201 + 1539 WP_001187196.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4693345..4723013 29668


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T211120 WP_000854735.1 NZ_CP080155:4710100-4710477 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T211120 NZ_CP104720:c144459-144178 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGAGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13663.32 Da        Isoelectric Point: 5.8640

>AT211120 WP_001285415.1 NZ_CP080155:4709679-4710053 [Escherichia coli]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT211120 NZ_CP104720:c144683-144456 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A067H947

References