Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3727905..3728523 Replicon chromosome
Accession NZ_CP080155
Organism Escherichia coli strain PK8261

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag KZY07_RS18005 Protein ID WP_001291435.1
Coordinates 3728305..3728523 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag KZY07_RS18000 Protein ID WP_000344800.1
Coordinates 3727905..3728279 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZY07_RS17990 (3722994) 3722994..3724187 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KZY07_RS17995 (3724210) 3724210..3727359 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
KZY07_RS18000 (3727905) 3727905..3728279 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
KZY07_RS18005 (3728305) 3728305..3728523 + 219 WP_001291435.1 HHA domain-containing protein Toxin
KZY07_RS18010 (3728695) 3728695..3729246 + 552 WP_000102559.1 maltose O-acetyltransferase -
KZY07_RS18015 (3729362) 3729362..3729832 + 471 WP_000136192.1 YlaC family protein -
KZY07_RS18020 (3729996) 3729996..3731546 + 1551 WP_001389864.1 cyclic-guanylate-specific phosphodiesterase PdeB -
KZY07_RS18025 (3731588) 3731588..3731941 - 354 WP_000878140.1 DUF1428 domain-containing protein -
KZY07_RS18035 (3732320) 3732320..3732631 + 312 WP_000409911.1 MGMT family protein -
KZY07_RS18040 (3732662) 3732662..3733234 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T211115 WP_001291435.1 NZ_CP080155:3728305-3728523 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T211115 NZ_CP104698:1813967-1814479 [Proteus mirabilis]
ATGACATTGAAGCTAACAGCACCTGAACCACTCAAATCAGTCCATCTGCTGGAGGGTTTTTCCTCCGGAGAAGAGGCTTT
AGATCTCTGGCTAAAAAACCGGGCAATGAGTAATCAAAACTCTGGTGCGTCGCGCACTTTTGTGACCACTTCGGATAACC
AGGTAATGGGGTATTATGCCTTGTCCACAGGGGTCATAAGCACCAATCAAGCCGTTGGTCGATTCCGCCGTAATATGCCC
ACCGACATACCCGTCATTCTACTTGGCAGGCTGGCGGTTGATACAAGGGCTAAAGGTCTTGGGATCGGAAGAGGACTTGT
TAAGGATGCCTGTCATCGCGTTATTCAGGCATCAGGGCTGGTGGGCATTAGAGGGGTGGTGGTTCACGCCCTTACTGACG
ATGCAAAACGGTTCTATGAGCATATTGGCTTCTTGCCTTCGCCGCTCGACCCGATGATGCTGATGATAACGCTTAGCGAT
CTGCAACTCGCTATGGGCATTTCCCCGAACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT211115 WP_000344800.1 NZ_CP080155:3727905-3728279 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT211115 NZ_CP104698:1813683-1813970 [Proteus mirabilis]
ATGCCAACTCAAAATGATGTGAGCGTAACACGTTCATCACTGAACCTGAGAATAAAGCCGGAAGATAAAATTCTGATCGA
CCGTGCCGCTAATGCAGTGGGGAAAAACCGTACCGAGTTTGTTCTGGAAGCTGCTCGACGTGCAGCTGAAGAAACGCTGG
CAGATCTGCGAGTCATTAACGTCAGTCCCGAAGTTTACCAGGAATTTATTAGCCAGCTTGATTCAGCGCCTGAGAGCAAT
GAGGCACTACGAAAAACAATGATGTCTAAATCCCCTTGGGAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References