Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3727905..3728523 | Replicon | chromosome |
Accession | NZ_CP080155 | ||
Organism | Escherichia coli strain PK8261 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | H5UYE2 |
Locus tag | KZY07_RS18005 | Protein ID | WP_001291435.1 |
Coordinates | 3728305..3728523 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | S1PTH5 |
Locus tag | KZY07_RS18000 | Protein ID | WP_000344800.1 |
Coordinates | 3727905..3728279 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KZY07_RS17990 (3722994) | 3722994..3724187 | + | 1194 | WP_001295833.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
KZY07_RS17995 (3724210) | 3724210..3727359 | + | 3150 | WP_001132480.1 | efflux RND transporter permease AcrB | - |
KZY07_RS18000 (3727905) | 3727905..3728279 | + | 375 | WP_000344800.1 | Hha toxicity modulator TomB | Antitoxin |
KZY07_RS18005 (3728305) | 3728305..3728523 | + | 219 | WP_001291435.1 | HHA domain-containing protein | Toxin |
KZY07_RS18010 (3728695) | 3728695..3729246 | + | 552 | WP_000102559.1 | maltose O-acetyltransferase | - |
KZY07_RS18015 (3729362) | 3729362..3729832 | + | 471 | WP_000136192.1 | YlaC family protein | - |
KZY07_RS18020 (3729996) | 3729996..3731546 | + | 1551 | WP_001389864.1 | cyclic-guanylate-specific phosphodiesterase PdeB | - |
KZY07_RS18025 (3731588) | 3731588..3731941 | - | 354 | WP_000878140.1 | DUF1428 domain-containing protein | - |
KZY07_RS18035 (3732320) | 3732320..3732631 | + | 312 | WP_000409911.1 | MGMT family protein | - |
KZY07_RS18040 (3732662) | 3732662..3733234 | - | 573 | WP_000779826.1 | YbaY family lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T211115 WP_001291435.1 NZ_CP080155:3728305-3728523 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T211115 NZ_CP104698:1813967-1814479 [Proteus mirabilis]
ATGACATTGAAGCTAACAGCACCTGAACCACTCAAATCAGTCCATCTGCTGGAGGGTTTTTCCTCCGGAGAAGAGGCTTT
AGATCTCTGGCTAAAAAACCGGGCAATGAGTAATCAAAACTCTGGTGCGTCGCGCACTTTTGTGACCACTTCGGATAACC
AGGTAATGGGGTATTATGCCTTGTCCACAGGGGTCATAAGCACCAATCAAGCCGTTGGTCGATTCCGCCGTAATATGCCC
ACCGACATACCCGTCATTCTACTTGGCAGGCTGGCGGTTGATACAAGGGCTAAAGGTCTTGGGATCGGAAGAGGACTTGT
TAAGGATGCCTGTCATCGCGTTATTCAGGCATCAGGGCTGGTGGGCATTAGAGGGGTGGTGGTTCACGCCCTTACTGACG
ATGCAAAACGGTTCTATGAGCATATTGGCTTCTTGCCTTCGCCGCTCGACCCGATGATGCTGATGATAACGCTTAGCGAT
CTGCAACTCGCTATGGGCATTTCCCCGAACTGA
ATGACATTGAAGCTAACAGCACCTGAACCACTCAAATCAGTCCATCTGCTGGAGGGTTTTTCCTCCGGAGAAGAGGCTTT
AGATCTCTGGCTAAAAAACCGGGCAATGAGTAATCAAAACTCTGGTGCGTCGCGCACTTTTGTGACCACTTCGGATAACC
AGGTAATGGGGTATTATGCCTTGTCCACAGGGGTCATAAGCACCAATCAAGCCGTTGGTCGATTCCGCCGTAATATGCCC
ACCGACATACCCGTCATTCTACTTGGCAGGCTGGCGGTTGATACAAGGGCTAAAGGTCTTGGGATCGGAAGAGGACTTGT
TAAGGATGCCTGTCATCGCGTTATTCAGGCATCAGGGCTGGTGGGCATTAGAGGGGTGGTGGTTCACGCCCTTACTGACG
ATGCAAAACGGTTCTATGAGCATATTGGCTTCTTGCCTTCGCCGCTCGACCCGATGATGCTGATGATAACGCTTAGCGAT
CTGCAACTCGCTATGGGCATTTCCCCGAACTGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14557.39 Da Isoelectric Point: 4.7395
>AT211115 WP_000344800.1 NZ_CP080155:3727905-3728279 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
Download Length: 375 bp
>AT211115 NZ_CP104698:1813683-1813970 [Proteus mirabilis]
ATGCCAACTCAAAATGATGTGAGCGTAACACGTTCATCACTGAACCTGAGAATAAAGCCGGAAGATAAAATTCTGATCGA
CCGTGCCGCTAATGCAGTGGGGAAAAACCGTACCGAGTTTGTTCTGGAAGCTGCTCGACGTGCAGCTGAAGAAACGCTGG
CAGATCTGCGAGTCATTAACGTCAGTCCCGAAGTTTACCAGGAATTTATTAGCCAGCTTGATTCAGCGCCTGAGAGCAAT
GAGGCACTACGAAAAACAATGATGTCTAAATCCCCTTGGGAGAAATGA
ATGCCAACTCAAAATGATGTGAGCGTAACACGTTCATCACTGAACCTGAGAATAAAGCCGGAAGATAAAATTCTGATCGA
CCGTGCCGCTAATGCAGTGGGGAAAAACCGTACCGAGTTTGTTCTGGAAGCTGCTCGACGTGCAGCTGAAGAAACGCTGG
CAGATCTGCGAGTCATTAACGTCAGTCCCGAAGTTTACCAGGAATTTATTAGCCAGCTTGATTCAGCGCCTGAGAGCAAT
GAGGCACTACGAAAAACAATGATGTCTAAATCCCCTTGGGAGAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 2MW2 | |
PDB | 1JW2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9QBQ5 |