Detailed information of TA system TA211110

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2574454..2576042
• Replicon: chromosome
• Accession: NZ_CP080155
• Organism: Escherichia coli strain PK8261

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: KZY07_RS12400
• Protein ID: WP_001546825.1
• Coordinates: 2574720..2576042 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KZY07_RS12395
• Protein ID: WP_001296726.1
• Coordinates: 2574454..2574720 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZY07_RS12395 (2574454)	2574454..2574720	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
KZY07_RS12400 (2574720)	2574720..2576042	+	1323	WP_001546825.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
KZY07_RS12405 (2576440)	2576440..2577339	-	900	WP_001057776.1	LysR family transcriptional regulator	-
KZY07_RS12410 (2577479)	2577479..2577787	+	309	WP_001221046.1	hypothetical protein	-
KZY07_RS12415 (2577796)	2577796..2578485	+	690	WP_000801313.1	type 1 glutamine amidotransferase domain-containing protein	-
KZY07_RS12420 (2578559)	2578559..2579506	+	948	WP_000854796.1	aldo/keto reductase	-
KZY07_RS12425 (2579609)	2579609..2579764	+	156	WP_001322415.1	hypothetical protein	-
KZY07_RS12430 (2579724)	2579724..2580143	+	420	WP_001322416.1	amidohydrolase family protein	-
KZY07_RS28090 (2580133)	2580133..2580285	+	153	WP_001322417.1	amidohydrolase family protein	-
KZY07_RS12440 (2580436)	2580436..2581008	+	573	WP_000789913.1	NAD(P)H-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49331.00 Da
• Isoelectric Point: 8.1369

>T211110 WP_001546825.1 NZ_CP080155:2574720-2576042 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHCRLSREYGIK

Nucleotide

• Length: 1323 bp

>T211110 NZ_CP104691:2338268-2338639 [Enterobacter hormaechei]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTGTTGAAGCTGCGGATGCGATTGA
GCATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTAATGGTGGGCGCTCGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTGATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATTGCGGAAAGAAGCGTTTTACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT211110 WP_001296726.1 NZ_CP080155:2574454-2574720 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT211110 NZ_CP104691:2338023-2338265 [Enterobacter hormaechei]
GTGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAATCT
CAAGCAATTGCGAAATCAACCACGTGCTGAACTGCTTCGGGAAGCGATAGAGCTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA