Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2023237..2024068 | Replicon | chromosome |
| Accession | NZ_CP080155 | ||
| Organism | Escherichia coli strain PK8261 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1P968 |
| Locus tag | KZY07_RS09650 | Protein ID | WP_000854814.1 |
| Coordinates | 2023237..2023611 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | B3Y195 |
| Locus tag | KZY07_RS09655 | Protein ID | WP_001285585.1 |
| Coordinates | 2023700..2024068 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZY07_RS09610 (2018633) | 2018633..2019799 | + | 1167 | WP_000830150.1 | serine-type D-Ala-D-Ala carboxypeptidase DacD | - |
| KZY07_RS09615 (2019918) | 2019918..2020391 | + | 474 | WP_001105389.1 | DNA gyrase inhibitor SbmC | - |
| KZY07_RS09620 (2020589) | 2020589..2021647 | + | 1059 | WP_001200891.1 | FUSC family protein | - |
| KZY07_RS09625 (2021819) | 2021819..2022148 | + | 330 | WP_000450409.1 | DUF496 family protein | - |
| KZY07_RS28065 (2022249) | 2022249..2022572 | - | 324 | WP_225343796.1 | EutP/PduV family microcompartment system protein | - |
| KZY07_RS28070 (2022551) | 2022551..2022631 | + | 81 | WP_023441679.1 | hypothetical protein | - |
| KZY07_RS09640 (2022920) | 2022920..2023000 | - | 81 | Protein_1897 | hypothetical protein | - |
| KZY07_RS09645 (2023046) | 2023046..2023240 | - | 195 | WP_000988600.1 | DUF5983 family protein | - |
| KZY07_RS09650 (2023237) | 2023237..2023611 | - | 375 | WP_000854814.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
| KZY07_RS09655 (2023700) | 2023700..2024068 | - | 369 | WP_001285585.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| KZY07_RS09660 (2024142) | 2024142..2024363 | - | 222 | WP_000692323.1 | DUF987 domain-containing protein | - |
| KZY07_RS09665 (2024426) | 2024426..2024902 | - | 477 | WP_001186726.1 | RadC family protein | - |
| KZY07_RS09670 (2024918) | 2024918..2025397 | - | 480 | WP_000860087.1 | antirestriction protein | - |
| KZY07_RS09675 (2025479) | 2025479..2026297 | - | 819 | WP_001234629.1 | DUF932 domain-containing protein | - |
| KZY07_RS09680 (2026397) | 2026397..2026630 | - | 234 | WP_001119729.1 | DUF905 family protein | - |
| KZY07_RS09685 (2026709) | 2026709..2027164 | - | 456 | WP_000581504.1 | IrmA family protein | - |
| KZY07_RS09690 (2027240) | 2027240..2028964 | - | 1725 | Protein_1907 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13898.94 Da Isoelectric Point: 7.8522
>T211101 WP_000854814.1 NZ_CP080155:c2023611-2023237 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T211101 NZ_CP104689:621070-621357 [Enterobacter hormaechei]
ATGCCTATAGAGTATGAATGGGATAGCAATAAGGCGAAAAGCAATCTGCAAAAACACGCCATTCGTTTTGAAGATGCAGT
TCTGGTTTTTGACGATCCCTGCCATTTGTCTGTTCAGGATCGTTATGAAAACGGGGAGTTTCGCTGGCAAACCATTGGTC
TTGTACAGGGTGTTATTGTCATTCTGGTCGCGCACACGGTACGTTTTGAAAGCGGGGATGAAATCATACGTATCATCAGT
GCGCGTAAAGCGGATCGTAAAGAGAGGAGGCGTTATGAGCATCGTTAA
ATGCCTATAGAGTATGAATGGGATAGCAATAAGGCGAAAAGCAATCTGCAAAAACACGCCATTCGTTTTGAAGATGCAGT
TCTGGTTTTTGACGATCCCTGCCATTTGTCTGTTCAGGATCGTTATGAAAACGGGGAGTTTCGCTGGCAAACCATTGGTC
TTGTACAGGGTGTTATTGTCATTCTGGTCGCGCACACGGTACGTTTTGAAAGCGGGGATGAAATCATACGTATCATCAGT
GCGCGTAAAGCGGATCGTAAAGAGAGGAGGCGTTATGAGCATCGTTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13593.48 Da Isoelectric Point: 6.3139
>AT211101 WP_001285585.1 NZ_CP080155:c2024068-2023700 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT211101 NZ_CP104689:621344-621646 [Enterobacter hormaechei]
ATGAGCATCGTTAAACATAAACGCGGTAGTGCACCGGAAGTGAGTGCCCGCCGGGAGGCTGAACTCAAAGCGCTGGCGGA
TAAACCCGACAGGGAAATTGATTACAGCGATATACCGGCCACGGAGGATGATCGCTGGGCCGGTGCCGTGCGGGGAAAAT
TCTATCGACCGCTCAAAACTCAGGCATCAGTACGCATTGACGCCGACGTGATGGAGTGGCTTAAACGGCCAGGGAAAGGT
TACCAGACGCGGCTTAATGCCATTTTGCGCGAGGCGATGCTGCGCGATCAGAACAAAAAATAA
ATGAGCATCGTTAAACATAAACGCGGTAGTGCACCGGAAGTGAGTGCCCGCCGGGAGGCTGAACTCAAAGCGCTGGCGGA
TAAACCCGACAGGGAAATTGATTACAGCGATATACCGGCCACGGAGGATGATCGCTGGGCCGGTGCCGTGCGGGGAAAAT
TCTATCGACCGCTCAAAACTCAGGCATCAGTACGCATTGACGCCGACGTGATGGAGTGGCTTAAACGGCCAGGGAAAGGT
TACCAGACGCGGCTTAATGCCATTTTGCGCGAGGCGATGCTGCGCGATCAGAACAAAAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829FY50 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9LW60 |