Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 792275..793144 Replicon chromosome
Accession NZ_CP080155
Organism Escherichia coli strain PK8261

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0U4BLW2
Locus tag KZY07_RS03930 Protein ID WP_059309235.1
Coordinates 792734..793144 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0X5FMN2
Locus tag KZY07_RS03925 Protein ID WP_039023579.1
Coordinates 792275..792643 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZY07_RS03895 (788353) 788353..789237 + 885 WP_000010380.1 YfjP family GTPase -
KZY07_RS28025 (789212) 789212..789343 - 132 WP_001349446.1 hypothetical protein -
KZY07_RS03900 (789423) 789423..790241 + 819 WP_001234688.1 DUF932 domain-containing protein -
KZY07_RS03905 (790323) 790323..790802 + 480 WP_000860074.1 antirestriction protein -
KZY07_RS03910 (790818) 790818..791294 + 477 WP_001349449.1 RadC family protein -
KZY07_RS03915 (791357) 791357..791578 + 222 WP_000692315.1 DUF987 domain-containing protein -
KZY07_RS27595 (791593) 791593..792225 + 633 Protein_772 antitoxin of toxin-antitoxin stability system -
KZY07_RS03925 (792275) 792275..792643 + 369 WP_039023579.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KZY07_RS03930 (792734) 792734..793144 + 411 WP_059309235.1 TA system toxin CbtA family protein Toxin
KZY07_RS03935 (793107) 793107..793256 + 150 Protein_775 DUF5983 family protein -
KZY07_RS03940 (793332) 793332..793529 + 198 WP_085975623.1 DUF957 domain-containing protein -
KZY07_RS03945 (793614) 793614..794455 + 842 Protein_777 DUF4942 domain-containing protein -
KZY07_RS03950 (794797) 794797..794967 + 171 Protein_778 IS110 family transposase -
KZY07_RS03955 (795778) 795778..796761 + 984 WP_001298261.1 KpsF/GutQ family sugar-phosphate isomerase -
KZY07_RS03960 (796833) 796833..797981 + 1149 WP_000905926.1 capsule polysaccharide export inner-membrane protein KpsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15234.33 Da        Isoelectric Point: 6.8522

>T211097 WP_059309235.1 NZ_CP080155:792734-793144 [Escherichia coli]
MKLLPDTHVREASCCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITLGSIRGRNDETFPDAGSRQH

Download         Length: 411 bp

>T211097 NZ_CP104682:c196864-196514 [Escherichia coli]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13672.49 Da        Isoelectric Point: 6.7393

>AT211097 WP_039023579.1 NZ_CP080155:792275-792643 [Escherichia coli]
VSDTLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT211097 NZ_CP104682:c196509-196207 [Escherichia coli]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U4BLW2

Antitoxin

Source ID Structure
AlphaFold DB A0A0X5FMN2

References