Detailed information of TA system TA021109

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 67037..68574
• Replicon: chromosome
• Accession: NC_006368
• Organism: Legionella pneumophila str. Paris

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LPP_RS00325
• Protein ID: WP_041173955.1
• Coordinates: 67037..68335 (-)
• Length: 433 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A3A6W1F4
• Locus tag: LPP_RS00330
• Protein ID: WP_011212708.1
• Coordinates: 68335..68574 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPP_RS00295	62518..63237	+	720	WP_011212701.1	C39 family peptidase	-
LPP_RS00300	63273..63833	+	561	WP_011212702.1	hypothetical protein	-
LPP_RS17035	63941..64102	+	162	WP_015444967.1	hypothetical protein	-
LPP_RS00305	64139..64543	-	405	WP_011212703.1	MerR family transcriptional regulator	-
LPP_RS00310	64613..65356	+	744	WP_011212704.1	glutaredoxin family protein	-
LPP_RS00315	65555..66646	+	1092	WP_011212705.1	hypothetical protein	-
LPP_RS00320	66688..67006	+	319	Protein_63	integrase	-
LPP_RS00325	67037..68335	-	1299	WP_041173955.1	type II toxin-antitoxin system HipA family toxin	Toxin
LPP_RS00330	68335..68574	-	240	WP_011212708.1	helix-turn-helix domain-containing protein	Antitoxin
LPP_RS00335	68668..68898	+	231	Protein_66	hypothetical protein	-
LPP_RS00340	69332..69697	+	366	WP_011212709.1	TraK family protein	-
LPP_RS00345	69995..70840	-	846	WP_011212710.1	hypothetical protein	-
LPP_RS00350	71169..71423	-	255	WP_041173947.1	hypothetical protein	-
LPP_RS00355	71961..72902	+	942	WP_011212712.1	hypothetical protein	-
LPP_RS16335	72911..73006	+	96	Protein_71	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (3-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (15-65)

Sequences

Toxin

Protein

• Length: 433 a.a.
• Molecular weight: 49362.61 Da
• Isoelectric Point: 8.0440

>T21109 WP_041173955.1 NC_006368:c68335-67037 [Legionella pneumophila str. Paris]
MRKLYILMNNELVGVLTQDNAGGLSFSYVADWISKPHSRPVSLSLPLINQRFSGEVVYNFFDNLLPDNPQIRARIQARFQ
AKSSRPFDLLALIGGDCVGAIQIVERIPQTQRLSIESHVVSEAEIARTLRSYQTSPLGMDKEDDEFRISIAGAQEKTAFL
YYQNEWHKPFGPTPTTHIFKLPIGYLPHQGIDLSESCENEHLCLLLASKFGLEVAKSKILQFEDEKVLVVERFDRKWSRD
NRYILRLPQEDLCQALGYSPNLKYQSDGGPGIKEIMQLLNGSQQPQKDRDEFFRAQVVYWCLGAIDAHAKNFSISIQPQG
GYQLTPLYDIISAYAIVEQKQLSFKKLKMAMALYGKNSHYKIDGIQKRHFIETAKYVQYSKIKAAQIFEQVIDRIDSAID
EVSTQLPNHFPEKIADPIFKGMRAFKERMIST

Nucleotide

• Length: 1299 bp

>T21109 NC_006368:c68335-67037 [Legionella pneumophila str. Paris]
ATGCGTAAATTATACATATTGATGAACAATGAGCTCGTGGGGGTGCTTACCCAGGATAATGCAGGTGGTTTGAGTTTTTC
CTACGTTGCTGACTGGATTTCCAAGCCGCATTCACGCCCAGTTTCTTTATCGTTACCGTTAATAAATCAAAGGTTTTCAG
GAGAAGTTGTTTATAACTTTTTTGATAATTTACTTCCCGATAATCCACAGATAAGAGCGAGAATTCAAGCTCGTTTTCAG
GCAAAATCATCGCGACCGTTTGATTTATTGGCGTTAATTGGCGGTGATTGTGTTGGTGCAATACAAATTGTTGAACGTAT
TCCTCAGACACAGCGTCTAAGCATTGAAAGTCACGTTGTCAGTGAGGCCGAGATAGCTCGTACTTTACGTTCTTACCAAA
CCTCACCACTGGGAATGGATAAAGAGGATGATGAGTTTAGAATCTCAATAGCCGGTGCTCAGGAAAAAACGGCTTTTCTA
TATTACCAAAATGAATGGCATAAACCATTTGGACCTACACCAACAACTCACATATTCAAATTACCTATTGGATATTTACC
ACATCAAGGAATTGATTTAAGTGAGAGTTGTGAAAATGAGCATCTCTGTTTACTACTAGCCAGCAAATTTGGTTTAGAGG
TTGCAAAATCAAAAATCTTACAATTCGAAGATGAAAAGGTGCTGGTTGTCGAAAGATTTGATAGAAAATGGAGTCGAGAT
AACCGTTATATACTCAGGTTACCGCAAGAAGACCTATGCCAAGCGTTGGGTTATTCACCAAATTTAAAATATCAGTCAGA
TGGTGGCCCCGGTATTAAAGAAATTATGCAGCTACTTAATGGCTCACAGCAGCCTCAAAAAGATAGAGATGAATTTTTCA
GAGCACAGGTTGTTTACTGGTGCCTTGGTGCTATTGATGCGCATGCCAAAAACTTCAGTATAAGTATACAACCACAAGGC
GGTTACCAGCTCACCCCCTTATACGACATCATTTCAGCCTATGCTATCGTGGAACAAAAACAGCTATCCTTTAAGAAATT
GAAAATGGCAATGGCTTTATATGGTAAAAATAGTCATTACAAGATTGACGGTATTCAAAAAAGACACTTTATTGAAACAG
CAAAATACGTTCAATATTCTAAAATTAAAGCAGCTCAGATTTTTGAACAAGTGATTGACCGTATTGATTCTGCTATCGAT
GAGGTCTCAACACAATTACCAAACCACTTCCCAGAAAAGATTGCAGATCCAATCTTCAAAGGGATGAGAGCTTTTAAGGA
GCGAATGATATCCACATAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9082.37 Da
• Isoelectric Point: 5.0628

>AT21109 WP_011212708.1 NC_006368:c68574-68335 [Legionella pneumophila str. Paris]
MIISSAKDLALYLNDKRKQLKMSQSEVADLVGLKQDTISKFENSPDNSRIDTLFRILSALNLNMSLVEKDQKTHEDIEW

Nucleotide

• Length: 240 bp

>AT21109 NC_006368:c68574-68335 [Legionella pneumophila str. Paris]
ATGATCATTAGCTCAGCAAAAGATTTAGCATTATATTTAAATGACAAGCGCAAACAACTCAAAATGAGTCAATCTGAAGT
TGCCGATTTAGTCGGCTTAAAACAGGATACCATATCAAAGTTTGAAAATAGCCCTGATAATAGTCGAATTGATACCTTAT
TTAGAATATTGTCCGCCCTAAATTTAAATATGAGCCTTGTTGAAAAAGATCAAAAAACTCATGAAGATATAGAATGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A3A6W1F4