Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 86666..87194 Replicon plasmid pLPP
Accession NC_006365
Organism Legionella pneumophila str. Paris

Toxin (Protein)


Gene name relE Uniprot ID A0A0A8UYT5
Locus tag LPP_RS15960 Protein ID WP_011212544.1
Coordinates 86666..86953 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0A8UU85
Locus tag LPP_RS15965 Protein ID WP_011212545.1
Coordinates 86943..87194 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPP_RS15930 81973..83481 + 1509 WP_011212538.1 DUF3987 domain-containing protein -
LPP_RS15935 83532..84107 + 576 WP_011212539.1 pyridoxamine 5'-phosphate oxidase family protein -
LPP_RS15940 84116..84427 + 312 WP_011212540.1 hypothetical protein -
LPP_RS15945 84483..84665 + 183 WP_011212541.1 hypothetical protein -
LPP_RS15950 84759..85634 - 876 WP_011212542.1 alpha/beta hydrolase -
LPP_RS15955 85692..86453 - 762 WP_011212543.1 MerR family transcriptional regulator -
LPP_RS15960 86666..86953 - 288 WP_011212544.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LPP_RS15965 86943..87194 - 252 WP_011212545.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LPP_RS15970 87443..87910 - 468 WP_011212546.1 hypothetical protein -
LPP_RS15975 88529..89350 - 822 WP_011212547.1 DUF4111 domain-containing protein -
LPP_RS15980 89334..89771 - 438 WP_010655396.1 DNA-binding protein -
LPP_RS15985 89758..90336 - 579 WP_010655397.1 nucleotidyltransferase domain-containing protein -
LPP_RS15990 90624..91505 - 882 WP_021436862.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-29 - 1..131885 131885


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-68)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11302.35 Da        Isoelectric Point: 10.4380

>T21107 WP_011212544.1 NC_006365:c86953-86666 [Legionella pneumophila str. Paris]
MIYELHFHPLALKEWKKLSKELQEQFKKLLKRRLENPHVISAKLSGHLKDCYKIKLHQAGYRLVYQVNDNKMILLVVAVG
KRNKNKVYESAEDRT

Download         Length: 288 bp

>T21107 NC_006365:c86953-86666 [Legionella pneumophila str. Paris]
ATGATCTATGAGTTACATTTCCATCCGCTTGCGTTAAAAGAATGGAAGAAACTATCGAAGGAGTTGCAGGAACAGTTTAA
AAAACTATTAAAACGGCGACTGGAAAATCCGCATGTTATTTCTGCCAAACTTAGTGGCCATCTTAAAGATTGCTATAAGA
TAAAATTGCATCAGGCCGGCTATAGATTGGTCTACCAAGTTAACGATAATAAAATGATTCTCCTTGTTGTTGCTGTAGGC
AAGCGAAACAAAAATAAAGTCTATGAGTCAGCAGAAGATAGGACTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9165.58 Da        Isoelectric Point: 4.5164

>AT21107 WP_011212545.1 NC_006365:c87194-86943 [Legionella pneumophila str. Paris]
MQTLYATQVASISELKKNPTKLINDAHGMPVVILNHNVAAAYLIPAETFEKLMDAVDESELKSIVEQRLSEPFTPVKVAL
DDL

Download         Length: 252 bp

>AT21107 NC_006365:c87194-86943 [Legionella pneumophila str. Paris]
ATGCAAACTTTATATGCAACACAAGTCGCTAGCATTAGCGAATTAAAGAAAAATCCCACAAAACTTATTAATGATGCTCA
TGGGATGCCCGTGGTGATTCTTAACCATAATGTAGCTGCTGCTTATTTAATTCCAGCAGAAACTTTTGAAAAACTGATGG
ATGCTGTTGACGAAAGCGAGCTAAAAAGCATTGTAGAACAACGCCTTTCAGAGCCCTTTACGCCAGTTAAGGTTGCGCTT
GATGATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8UYT5

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8UU85

References