Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4618354..4619152 Replicon chromosome
Accession NZ_CP080139
Organism Escherichia coli strain PK8241

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0V7WHV8
Locus tag KZY05_RS23290 Protein ID WP_001506713.1
Coordinates 4618775..4619152 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1E5M1V9
Locus tag KZY05_RS23285 Protein ID WP_052913677.1
Coordinates 4618354..4618728 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZY05_RS23245 (4613798) 4613798..4614295 + 498 Protein_4579 integrase arm-type DNA-binding domain-containing protein -
KZY05_RS23255 (4615605) 4615605..4616042 + 438 Protein_4581 integrase core domain-containing protein -
KZY05_RS23260 (4616052) 4616052..4616603 + 552 Protein_4582 DUF932 domain-containing protein -
KZY05_RS23265 (4616603) 4616603..4616848 + 246 WP_001164975.1 hypothetical protein -
KZY05_RS23270 (4616942) 4616942..4617415 + 474 WP_001368734.1 antirestriction protein -
KZY05_RS23275 (4617431) 4617431..4617907 + 477 WP_069723416.1 RadC family protein -
KZY05_RS23280 (4617970) 4617970..4618191 + 222 WP_000692311.1 DUF987 domain-containing protein -
KZY05_RS23285 (4618354) 4618354..4618728 + 375 WP_052913677.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KZY05_RS23290 (4618775) 4618775..4619152 + 378 WP_001506713.1 TA system toxin CbtA family protein Toxin
KZY05_RS23295 (4619149) 4619149..4619637 + 489 WP_001470575.1 DUF5983 family protein -
KZY05_RS23300 (4619649) 4619649..4619846 + 198 WP_000839249.1 DUF957 domain-containing protein -
KZY05_RS23305 (4619931) 4619931..4620080 + 150 Protein_4591 hypothetical protein -
KZY05_RS29520 (4620848) 4620848..4620991 - 144 Protein_4592 HNH endonuclease -
KZY05_RS23310 (4621128) 4621128..4621778 + 651 WP_001037966.1 HNH endonuclease -
KZY05_RS23315 (4621786) 4621786..4622766 - 981 WP_001295601.1 sialate O-acetylesterase -
KZY05_RS23320 (4622831) 4622831..4623937 - 1107 WP_001353974.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fimB / fimE 4613798..4627802 14004


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-118)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14178.26 Da        Isoelectric Point: 7.8045

>T211041 WP_001506713.1 NZ_CP080139:4618775-4619152 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYITVNNITLGKHPEAKR

Download         Length: 378 bp

>T211041 NZ_CP104665:c4604287-4604114 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGCGCATTCCTGGTCGGAATAACCTGGCCAATGAGTTTACCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13676.47 Da        Isoelectric Point: 6.3139

>AT211041 WP_052913677.1 NZ_CP080139:4618354-4618728 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS

Download         Length: 375 bp

>AT211041 NZ_CP104665:c4604611-4604315 [Escherichia coli]
ATGGAAGGTAAAAATAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V7WHV8

Antitoxin

Source ID Structure
AlphaFold DB A0A1E5M1V9

References