Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4249062..4249987 Replicon chromosome
Accession NZ_CP080139
Organism Escherichia coli strain PK8241

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag KZY05_RS21310 Protein ID WP_014640052.1
Coordinates 4249601..4249987 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag KZY05_RS21305 Protein ID WP_024174200.1
Coordinates 4249062..4249571 (+) Length 170 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZY05_RS21275 (4244082) 4244082..4244690 + 609 WP_000646078.1 transcriptional repressor LexA -
KZY05_RS21280 (4244763) 4244763..4246088 + 1326 WP_001326646.1 MATE family efflux transporter DinF -
KZY05_RS21285 (4246204) 4246204..4246413 + 210 WP_001030593.1 CsbD family protein -
KZY05_RS21290 (4246455) 4246455..4246970 - 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
KZY05_RS29875 (4247288) 4247288..4247539 + 252 Protein_4186 DUF2713 domain-containing protein -
KZY05_RS21295 (4247534) 4247534..4248280 + 747 WP_001395163.1 DUF2713 family protein -
KZY05_RS21300 (4248641) 4248641..4248745 + 105 Protein_4188 tRNA-dihydrouridine synthase -
KZY05_RS21305 (4249062) 4249062..4249571 + 510 WP_024174200.1 Panacea domain-containing protein Antitoxin
KZY05_RS21310 (4249601) 4249601..4249987 + 387 WP_014640052.1 hypothetical protein Toxin
KZY05_RS21315 (4250027) 4250027..4250200 + 174 WP_000390072.1 hypothetical protein -
KZY05_RS21320 (4250248) 4250248..4250529 - 282 WP_001093918.1 pyocin activator PrtN family protein -
KZY05_RS21325 (4250566) 4250566..4251138 - 573 WP_069723195.1 3'-5' exonuclease -
KZY05_RS29455 (4251138) 4251138..4251329 - 192 WP_232380427.1 DUF551 domain-containing protein -
KZY05_RS29460 (4251576) 4251576..4251890 - 315 Protein_4195 DUF551 domain-containing protein -
KZY05_RS21335 (4251893) 4251893..4252084 - 192 WP_001014290.1 hypothetical protein -
KZY05_RS21340 (4252086) 4252086..4252685 - 600 WP_069723370.1 ead/Ea22-like family protein -
KZY05_RS21345 (4252682) 4252682..4253167 - 486 WP_069723371.1 class I SAM-dependent methyltransferase -
KZY05_RS21350 (4253164) 4253164..4253514 - 351 WP_001242740.1 hypothetical protein -
KZY05_RS21355 (4253505) 4253505..4254041 - 537 WP_000008232.1 5'-deoxynucleotidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - espX5 4243604..4310198 66594


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(6-116)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T211038 WP_014640052.1 NZ_CP080139:4249601-4249987 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

>T211038 NZ_CP104665:c4198411-4198097 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAATC
CAATCCTTTTACTGGTAGATGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCACACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 170 a.a.        Molecular weight: 19559.39 Da        Isoelectric Point: 5.3338

>AT211038 WP_024174200.1 NZ_CP080139:4249062-4249571 [Escherichia coli]
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Download         Length: 510 bp

>AT211038 NZ_CP104665:c4198647-4198414 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACA
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References