Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3052363..3053198 | Replicon | chromosome |
| Accession | NZ_CP080139 | ||
| Organism | Escherichia coli strain PK8241 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A1C0Y405 |
| Locus tag | KZY05_RS15625 | Protein ID | WP_001774607.1 |
| Coordinates | 3052821..3053198 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A1M2U6P5 |
| Locus tag | KZY05_RS15620 | Protein ID | WP_001774606.1 |
| Coordinates | 3052363..3052731 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZY05_RS15575 (3047395) | 3047395..3048075 | + | 681 | WP_032082725.1 | WYL domain-containing protein | - |
| KZY05_RS15580 (3048223) | 3048223..3048900 | + | 678 | WP_001097305.1 | hypothetical protein | - |
| KZY05_RS15585 (3048906) | 3048906..3049139 | + | 234 | WP_001278287.1 | DUF905 family protein | - |
| KZY05_RS15590 (3049238) | 3049238..3050056 | + | 819 | WP_016238867.1 | DUF932 domain-containing protein | - |
| KZY05_RS15595 (3050095) | 3050095..3050295 | - | 201 | WP_157917024.1 | hypothetical protein | - |
| KZY05_RS15600 (3050395) | 3050395..3050874 | + | 480 | WP_032152717.1 | antirestriction protein | - |
| KZY05_RS15605 (3050890) | 3050890..3051366 | + | 477 | WP_001297237.1 | RadC family protein | - |
| KZY05_RS15610 (3051429) | 3051429..3051650 | + | 222 | WP_000692312.1 | DUF987 domain-containing protein | - |
| KZY05_RS15615 (3051669) | 3051669..3052313 | + | 645 | WP_001774605.1 | hypothetical protein | - |
| KZY05_RS15620 (3052363) | 3052363..3052731 | + | 369 | WP_001774606.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| KZY05_RS15625 (3052821) | 3052821..3053198 | + | 378 | WP_001774607.1 | TA system toxin CbtA family protein | Toxin |
| KZY05_RS15630 (3053195) | 3053195..3053683 | + | 489 | WP_001774608.1 | DUF5983 family protein | - |
| KZY05_RS15635 (3053695) | 3053695..3053892 | + | 198 | WP_032152719.1 | DUF957 domain-containing protein | - |
| KZY05_RS15640 (3053977) | 3053977..3054819 | + | 843 | WP_032152755.1 | DUF4942 domain-containing protein | - |
| KZY05_RS15645 (3055100) | 3055100..3055636 | - | 537 | WP_000942783.1 | GspM family type II secretion system protein YghD | - |
| KZY05_RS15650 (3055638) | 3055638..3056816 | - | 1179 | WP_000094962.1 | type II secretion system protein GspL | - |
| KZY05_RS15655 (3056813) | 3056813..3057790 | - | 978 | WP_001460058.1 | type II secretion system minor pseudopilin GspK | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14218.20 Da Isoelectric Point: 7.8045
>T211034 WP_001774607.1 NZ_CP080139:3052821-3053198 [Escherichia coli]
MKTLPDTHVREASRCPPPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDTVNFLVEKYALIRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
MKTLPDTHVREASRCPPPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDTVNFLVEKYALIRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
Download Length: 378 bp
>T211034 NZ_CP104665:3331365-3331751 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGTAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGTAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13593.31 Da Isoelectric Point: 5.8746
>AT211034 WP_001774606.1 NZ_CP080139:3052363-3052731 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT211034 NZ_CP104665:3331741-3332070 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1C0Y405 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M2U6P5 |