Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1234593..1235231 Replicon chromosome
Accession NZ_CP080139
Organism Escherichia coli strain PK8241

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag KZY05_RS06560 Protein ID WP_000813794.1
Coordinates 1234593..1234769 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KZY05_RS06565 Protein ID WP_001270286.1
Coordinates 1234815..1235231 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZY05_RS06540 (1230212) 1230212..1231387 - 1176 WP_001236265.1 BenE family transporter YdcO -
KZY05_RS06545 (1231479) 1231479..1232015 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
KZY05_RS06550 (1232088) 1232088..1234049 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
KZY05_RS06555 (1234141) 1234141..1234371 - 231 WP_000494244.1 YncJ family protein -
KZY05_RS06560 (1234593) 1234593..1234769 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
KZY05_RS06565 (1234815) 1234815..1235231 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
KZY05_RS06570 (1235310) 1235310..1236719 + 1410 WP_000760625.1 PLP-dependent aminotransferase family protein -
KZY05_RS06575 (1236961) 1236961..1238106 + 1146 WP_000047429.1 ABC transporter substrate-binding protein -
KZY05_RS06580 (1238124) 1238124..1239137 + 1014 WP_000220393.1 ABC transporter ATP-binding protein -
KZY05_RS06585 (1239138) 1239138..1240079 + 942 WP_001251319.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T211022 WP_000813794.1 NZ_CP080139:1234593-1234769 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T211022 NZ_CP104665:220732-220839 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT211022 WP_001270286.1 NZ_CP080139:1234815-1235231 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT211022 NZ_CP104665:c220683-220620 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References