210994

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 919512..920166 Replicon chromosome
Accession NZ_CP080133
Organism Escherichia coli strain PK8277

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag KZY04_RS04540 Protein ID WP_000244777.1
Coordinates 919759..920166 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag KZY04_RS04535 Protein ID WP_000354046.1
Coordinates 919512..919778 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZY04_RS04510 (914681) 914681..915424 + 744 WP_000951962.1 SDR family oxidoreductase -
KZY04_RS04515 (915481) 915481..916914 - 1434 WP_001338826.1 6-phospho-beta-glucosidase BglA -
KZY04_RS04520 (916959) 916959..917270 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
KZY04_RS04525 (917434) 917434..918093 + 660 WP_000250274.1 hemolysin III family protein -
KZY04_RS04530 (918289) 918289..919269 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
KZY04_RS04535 (919512) 919512..919778 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
KZY04_RS04540 (919759) 919759..920166 + 408 WP_000244777.1 protein YgfX Toxin
KZY04_RS04545 (920206) 920206..920727 - 522 WP_001055874.1 flavodoxin FldB -
KZY04_RS04550 (920839) 920839..921735 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
KZY04_RS04555 (921760) 921760..922470 + 711 WP_000715216.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KZY04_RS04560 (922476) 922476..924209 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T210994 WP_000244777.1 NZ_CP080133:919759-920166 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T210994 NZ_CP104653:93190-93471 [Acinetobacter variabilis]
ATGGCTATTAAACTTCGCAAATGGGACAGTGCTGAGCATCTTAAAACAGAGGATGATATGCAGGCTTACTTACAAGCATG
TATTGAAGAATCTAATGGCGATGCCGCATTCATTGCAAAGGCTTTAGGTAACATTGCAAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGCTTAGGCCGAGAAAGTCTTTATAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT210994 WP_000354046.1 NZ_CP080133:919512-919778 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT210994 NZ_CP104653:92887-93189 [Acinetobacter variabilis]
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTCACCAAGTTAAAAGACCAGCAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAGCCGGTCGGTGAAGGTGTTTCTGAATTACGTTTCT
TCTTTGGGCCAGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTTGTTATTCTTTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTGCAATTGGCACAAGATTTAGAGGAGGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References