Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 783375..784173 | Replicon | chromosome |
| Accession | NZ_CP080133 | ||
| Organism | Escherichia coli strain PK8277 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | U9XMP3 |
| Locus tag | KZY04_RS03840 | Protein ID | WP_000854735.1 |
| Coordinates | 783375..783752 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A1M1EW42 |
| Locus tag | KZY04_RS03845 | Protein ID | WP_032153712.1 |
| Coordinates | 783799..784173 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZY04_RS03805 (778982) | 778982..779095 | + | 114 | Protein_752 | IS1 family transposase | - |
| KZY04_RS03810 (779343) | 779343..780605 | - | 1263 | WP_130562364.1 | integrase arm-type DNA-binding domain-containing protein | - |
| KZY04_RS03815 (781069) | 781069..781395 | - | 327 | WP_000779483.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KZY04_RS03820 (781392) | 781392..781655 | - | 264 | WP_025492088.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| KZY04_RS03825 (781727) | 781727..782593 | - | 867 | WP_032153714.1 | DUF4942 domain-containing protein | - |
| KZY04_RS03830 (782678) | 782678..782875 | - | 198 | WP_000839265.1 | DUF957 domain-containing protein | - |
| KZY04_RS03835 (782887) | 782887..783378 | - | 492 | WP_023155722.1 | DUF5983 family protein | - |
| KZY04_RS03840 (783375) | 783375..783752 | - | 378 | WP_000854735.1 | TA system toxin CbtA family protein | Toxin |
| KZY04_RS03845 (783799) | 783799..784173 | - | 375 | WP_032153712.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| KZY04_RS03850 (784253) | 784253..784474 | - | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
| KZY04_RS03855 (784543) | 784543..785019 | - | 477 | WP_001186715.1 | RadC family protein | - |
| KZY04_RS03860 (785035) | 785035..785520 | - | 486 | WP_032153711.1 | antirestriction protein | - |
| KZY04_RS03865 (785612) | 785612..786430 | - | 819 | WP_001234693.1 | DUF932 domain-containing protein | - |
| KZY04_RS03870 (786521) | 786521..786730 | - | 210 | WP_023155727.1 | DUF905 family protein | - |
| KZY04_RS03875 (786760) | 786760..787437 | - | 678 | WP_023155728.1 | hypothetical protein | - |
| KZY04_RS03880 (787556) | 787556..788440 | - | 885 | WP_024166630.1 | 50S ribosome-binding GTPase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 755610..804309 | 48699 | |
| - | flank | IS/Tn | - | - | 777981..778904 | 923 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14061.07 Da Isoelectric Point: 8.2904
>T210993 WP_000854735.1 NZ_CP080133:c783752-783375 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T210993 NZ_CP104653:92887-93189 [Acinetobacter variabilis]
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTCACCAAGTTAAAAGACCAGCAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAGCCGGTCGGTGAAGGTGTTTCTGAATTACGTTTCT
TCTTTGGGCCAGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTTGTTATTCTTTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTGCAATTGGCACAAGATTTAGAGGAGGAGCTATAA
ATGTACTCAATATATACCACTGAAGTCTTTGATGACTGGTTCACCAAGTTAAAAGACCAGCAGGCAAAAAGACGCATACA
AGTCCGAATTGATCGGGTTGAAGATGGAAACTTTGGAGATACTGAGCCGGTCGGTGAAGGTGTTTCTGAATTACGTTTCT
TCTTTGGGCCAGGCTATAGGATTTATTACTGCAAGCAAGGGCAAAGGGTTGTTATTCTTTTAGCAGGCGGAGATAAGTCT
ACGCAAAGTAAAGATATAAAACTTGCCCTGCAATTGGCACAAGATTTAGAGGAGGAGCTATAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13697.51 Da Isoelectric Point: 6.6240
>AT210993 WP_032153712.1 NZ_CP080133:c784173-783799 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS
Download Length: 375 bp
>AT210993 NZ_CP104653:93190-93471 [Acinetobacter variabilis]
ATGGCTATTAAACTTCGCAAATGGGACAGTGCTGAGCATCTTAAAACAGAGGATGATATGCAGGCTTACTTACAAGCATG
TATTGAAGAATCTAATGGCGATGCCGCATTCATTGCAAAGGCTTTAGGTAACATTGCAAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGCTTAGGCCGAGAAAGTCTTTATAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA
ATGGCTATTAAACTTCGCAAATGGGACAGTGCTGAGCATCTTAAAACAGAGGATGATATGCAGGCTTACTTACAAGCATG
TATTGAAGAATCTAATGGCGATGCCGCATTCATTGCAAAGGCTTTAGGTAACATTGCAAAAGCTAAAGGAATGGCTCAAT
TATCACGAGATACAGGCTTAGGCCGAGAAAGTCTTTATAAAGCACTTTCTGGTGATGTTAACCCTAGTTTTGATACTGTG
ATTAAAGTTGTAAAAGCACTGAATTTACGCTTAGCAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | U9XMP3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M1EW42 |