Detailed information of TA system TA210948

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 4127366..4128291
• Replicon: chromosome
• Accession: NZ_CP080121
• Organism: Escherichia coli strain PK8217

Toxin (Protein)

• Gene name: panT
• Uniprot ID: A0A067H892
• Locus tag: KZO72_RS20085
• Protein ID: WP_000133216.1
• Coordinates: 4127366..4127785 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: KZO72_RS20090
• Protein ID: WP_024174200.1
• Coordinates: 4127782..4128291 (-)
• Length: 170 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZO72_RS20050 (4122912)	4122912..4123112	-	201	WP_000649477.1	YdaS family helix-turn-helix protein	-
KZO72_RS20055 (4123203)	4123203..4123877	+	675	WP_000859461.1	LexA family transcriptional regulator	-
KZO72_RS20060 (4124564)	4124564..4124926	+	363	WP_000135680.1	protein YfdP	-
KZO72_RS20065 (4124992)	4124992..4125816	+	825	WP_000081311.1	DUF2303 family protein	-
KZO72_RS20070 (4126005)	4126005..4126787	+	783	WP_047654657.1	hypothetical protein	-
KZO72_RS20075 (4126824)	4126824..4127105	+	282	WP_001093916.1	pyocin activator PrtN family protein	-
KZO72_RS20080 (4127153)	4127153..4127326	-	174	WP_000390072.1	hypothetical protein	-
KZO72_RS20085 (4127366)	4127366..4127785	-	420	WP_000133216.1	hypothetical protein	Toxin
KZO72_RS20090 (4127782)	4127782..4128291	-	510	WP_024174200.1	Panacea domain-containing protein	Antitoxin
KZO72_RS20095 (4128608)	4128608..4128712	-	105	Protein_3954	tRNA-dihydrouridine synthase	-
KZO72_RS20100 (4129073)	4129073..4129819	-	747	WP_001395163.1	DUF2713 family protein	-
KZO72_RS25025 (4129810)	4129810..4130064	-	255	WP_059040151.1	protein YjbL	-
KZO72_RS20105 (4130382)	4130382..4130897	+	516	WP_001295691.1	zinc uptake transcriptional repressor Zur	-
KZO72_RS20110 (4130939)	4130939..4131148	-	210	WP_001030593.1	CsbD family protein	-
KZO72_RS20115 (4131264)	4131264..4132589	-	1326	WP_001326646.1	MATE family efflux transporter DinF	-
KZO72_RS20120 (4132662)	4132662..4133270	-	609	WP_000646078.1	transcriptional repressor LexA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	espX4	4080302..4140610	60308

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (6-116)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15806.90 Da
• Isoelectric Point: 5.8917

>T210948 WP_000133216.1 NZ_CP080121:c4127785-4127366 [Escherichia coli]
MTDYQPYRKGTVLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAI
IWRVDNMVRKQRSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Nucleotide

• Length: 420 bp

>T210948 NZ_CP104647:c2887654-2887313 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin

Protein

• Length: 170 a.a.
• Molecular weight: 19559.39 Da
• Isoelectric Point: 5.3338

>AT210948 WP_024174200.1 NZ_CP080121:c4128291-4127782 [Escherichia coli]
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Nucleotide

• Length: 510 bp

>AT210948 NZ_CP104647:2887649-2887725 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A067H892