Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2364484..2365459 Replicon chromosome
Accession NC_006274
Organism Bacillus cereus E33L

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A7U6C7L7
Locus tag BCE33L_RS12175 Protein ID WP_002021399.1
Coordinates 2364484..2365221 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1J9W3Q2
Locus tag BCE33L_RS12180 Protein ID WP_000594606.1
Coordinates 2365334..2365459 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCE33L_RS12150 2359559..2360269 + 711 WP_000787479.1 class I SAM-dependent methyltransferase -
BCE33L_RS12155 2360389..2360796 + 408 WP_000072487.1 VOC family protein -
BCE33L_RS12160 2361116..2362801 - 1686 WP_011198735.1 alpha-keto acid decarboxylase family protein -
BCE33L_RS12165 2362908..2363390 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
BCE33L_RS12170 2363558..2364295 + 738 WP_000594155.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
BCE33L_RS12175 2364484..2365221 + 738 WP_002021399.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
BCE33L_RS12180 2365334..2365459 + 126 WP_000594606.1 hypothetical protein Antitoxin
BCE33L_RS12185 2365535..2365711 + 177 WP_000852613.1 hypothetical protein -
BCE33L_RS12190 2365755..2366030 - 276 WP_001041552.1 hypothetical protein -
BCE33L_RS12195 2366307..2366543 - 237 WP_001021691.1 hypothetical protein -
BCE33L_RS32510 2366875..2367051 + 177 WP_000808045.1 hypothetical protein -
BCE33L_RS12205 2367195..2368664 + 1470 WP_000287519.1 beta-Ala-His dipeptidase -
BCE33L_RS12210 2369245..2369715 - 471 WP_000771838.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28331.03 Da        Isoelectric Point: 8.2638

>T21094 WP_002021399.1 NC_006274:2364484-2365221 [Bacillus cereus E33L]
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T21094 NC_006274:2364484-2365221 [Bacillus cereus E33L]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACAGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGCGGTATCCGTTCTCAATTTAGTACGATTATTCCATTAGA
GTACATTGAGCAATTGAATGAGCAGAAAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4860.23 Da        Isoelectric Point: 3.9507

>AT21094 WP_000594606.1 NC_006274:2365334-2365459 [Bacillus cereus E33L]
VIKNNDNDFFKEDNEDTTDFSLIKGDTLQQVEDLEDELKRK

Download         Length: 126 bp

>AT21094 NC_006274:2365334-2365459 [Bacillus cereus E33L]
GTGATAAAAAATAATGATAATGATTTTTTTAAAGAAGACAATGAAGATACAACGGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGATTTAGAAGATGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U6C7L7

Antitoxin

Source ID Structure
AlphaFold DB A0A1J9W3Q2

References