Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 4394387..4394907 | Replicon | chromosome |
Accession | NZ_CP080120 | ||
Organism | Escherichia coli strain M24 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | A0A061KX66 |
Locus tag | KZX72_RS21420 | Protein ID | WP_001160964.1 |
Coordinates | 4394387..4394671 (-) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | V0VEX8 |
Locus tag | KZX72_RS21425 | Protein ID | WP_000125566.1 |
Coordinates | 4394674..4394907 (-) | Length | 78 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KZX72_RS21395 (4390032) | 4390032..4391318 | + | 1287 | WP_000800457.1 | peptidylprolyl isomerase SurA | - |
KZX72_RS21400 (4391318) | 4391318..4392307 | + | 990 | WP_000241227.1 | 4-hydroxythreonine-4-phosphate dehydrogenase PdxA | - |
KZX72_RS21405 (4392304) | 4392304..4393125 | + | 822 | WP_001065365.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
KZX72_RS21410 (4393128) | 4393128..4393505 | + | 378 | WP_000610901.1 | Co2+/Mg2+ efflux protein ApaG | - |
KZX72_RS21415 (4393512) | 4393512..4394360 | + | 849 | WP_000257181.1 | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH | - |
KZX72_RS21420 (4394387) | 4394387..4394671 | - | 285 | WP_001160964.1 | CcdB family protein | Toxin |
KZX72_RS21425 (4394674) | 4394674..4394907 | - | 234 | WP_000125566.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
KZX72_RS21430 (4394993) | 4394993..4395472 | - | 480 | WP_000624375.1 | type 3 dihydrofolate reductase | - |
KZX72_RS21435 (4395664) | 4395664..4397526 | - | 1863 | WP_000377106.1 | glutathione-regulated potassium-efflux system protein KefC | - |
KZX72_RS21440 (4397519) | 4397519..4398049 | - | 531 | WP_000600725.1 | glutathione-regulated potassium-efflux system oxidoreductase KefF | - |
KZX72_RS21445 (4398157) | 4398157..4399488 | - | 1332 | WP_001183209.1 | MFS transporter | - |
KZX72_RS21450 (4399547) | 4399547..4399834 | - | 288 | WP_000203744.1 | ferredoxin-like protein FixX | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 10692.54 Da Isoelectric Point: 10.3030
>T210923 WP_001160964.1 NZ_CP080120:c4394671-4394387 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLIDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIK
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLIDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIK
Download Length: 285 bp
>T210923 NZ_CP104645:2988943-2989257 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCAGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
ATGCAATTTACGGTATACCGCAGTCGCAGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
Antitoxin
Download Length: 78 a.a. Molecular weight: 8530.53 Da Isoelectric Point: 5.8062
>AT210923 WP_000125566.1 NZ_CP080120:c4394907-4394674 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF
Download Length: 234 bp
>AT210923 NZ_CP104645:2988707-2988940 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CTGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CTGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A061KX66 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LTM9 |