Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2099531..2100362 Replicon chromosome
Accession NZ_CP080120
Organism Escherichia coli strain M24

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag KZX72_RS09825 Protein ID WP_000854815.1
Coordinates 2099531..2099905 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag KZX72_RS09830 Protein ID WP_001280918.1
Coordinates 2099994..2100362 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX72_RS09785 (2094927) 2094927..2096093 + 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
KZX72_RS09790 (2096212) 2096212..2096685 + 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
KZX72_RS09795 (2096883) 2096883..2097941 + 1059 WP_001200889.1 FUSC family protein -
KZX72_RS09800 (2098113) 2098113..2098442 + 330 WP_000450409.1 DUF496 family protein -
KZX72_RS25650 (2098543) 2098543..2098866 - 324 WP_225469267.1 EutP/PduV family microcompartment system protein -
KZX72_RS25655 (2098845) 2098845..2098925 + 81 WP_023441679.1 hypothetical protein -
KZX72_RS09815 (2099214) 2099214..2099294 - 81 Protein_1935 hypothetical protein -
KZX72_RS09820 (2099340) 2099340..2099534 - 195 WP_000988600.1 DUF5983 family protein -
KZX72_RS09825 (2099531) 2099531..2099905 - 375 WP_000854815.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
KZX72_RS09830 (2099994) 2099994..2100362 - 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KZX72_RS09835 (2100378) 2100378..2101022 - 645 WP_000086752.1 hypothetical protein -
KZX72_RS09840 (2101041) 2101041..2101262 - 222 WP_000692345.1 DUF987 domain-containing protein -
KZX72_RS09845 (2101325) 2101325..2101801 - 477 WP_001186200.1 RadC family protein -
KZX72_RS09850 (2101817) 2101817..2102290 - 474 WP_001542276.1 antirestriction protein -
KZX72_RS09855 (2102384) 2102384..2102629 - 246 WP_001164966.1 hypothetical protein -
KZX72_RS09860 (2102629) 2102629..2103447 - 819 WP_001542275.1 DUF932 domain-containing protein -
KZX72_RS09865 (2103668) 2103668..2104078 - 411 WP_000846703.1 hypothetical protein -
KZX72_RS09870 (2104094) 2104094..2104444 - 351 Protein_1946 hypothetical protein -
KZX72_RS09875 (2104527) 2104527..2105273 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T210910 WP_000854815.1 NZ_CP080120:c2099905-2099531 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T210910 NZ_CP104643:c4571073-4570582 [Salmonella enterica]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT210910 WP_001280918.1 NZ_CP080120:c2100362-2099994 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT210910 NZ_CP104643:c4571363-4571070 [Salmonella enterica]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References