Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sanaTA/AbiEii-DUF6088 |
| Location | 927024..928305 | Replicon | chromosome |
| Accession | NZ_CP080120 | ||
| Organism | Escherichia coli strain M24 | ||
Toxin (Protein)
| Gene name | sanaT | Uniprot ID | A0A1X3JHM4 |
| Locus tag | KZX72_RS04445 | Protein ID | WP_001114681.1 |
| Coordinates | 927024..927917 (-) | Length | 298 a.a. |
Antitoxin (Protein)
| Gene name | sanaA | Uniprot ID | V0YCI1 |
| Locus tag | KZX72_RS04450 | Protein ID | WP_000208383.1 |
| Coordinates | 927910..928305 (-) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZX72_RS04425 (922723) | 922723..923478 | - | 756 | Protein_879 | IS21-like element ISEc10 family helper ATPase IstB | - |
| KZX72_RS04430 (923475) | 923475..924974 | - | 1500 | WP_000174401.1 | IS21-like element ISEc10 family transposase | - |
| KZX72_RS04435 (925323) | 925323..925493 | - | 171 | Protein_881 | IS110 family transposase | - |
| KZX72_RS04440 (925605) | 925605..926522 | - | 918 | WP_000520337.1 | IS5-like element ISEc35 family transposase | - |
| KZX72_RS04445 (927024) | 927024..927917 | - | 894 | WP_001114681.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| KZX72_RS04450 (927910) | 927910..928305 | - | 396 | WP_000208383.1 | DUF6088 family protein | Antitoxin |
| KZX72_RS04455 (928374) | 928374..929219 | - | 846 | WP_023281696.1 | DUF4942 domain-containing protein | - |
| KZX72_RS04460 (929304) | 929304..929501 | - | 198 | WP_000839293.1 | DUF957 domain-containing protein | - |
| KZX72_RS04465 (929518) | 929518..930006 | - | 489 | WP_000761699.1 | DUF5983 family protein | - |
| KZX72_RS04470 (930003) | 930003..930380 | - | 378 | WP_000854689.1 | TA system toxin CbtA family protein | - |
| KZX72_RS04475 (930457) | 930457..930837 | - | 381 | WP_001285598.1 | type IV toxin-antitoxin system YeeU family antitoxin | - |
| KZX72_RS04480 (930887) | 930887..931531 | - | 645 | WP_000094916.1 | hypothetical protein | - |
| KZX72_RS04485 (931550) | 931550..931771 | - | 222 | WP_000692329.1 | DUF987 domain-containing protein | - |
| KZX72_RS04490 (931834) | 931834..932310 | - | 477 | WP_001186726.1 | RadC family protein | - |
| KZX72_RS04495 (932326) | 932326..932811 | - | 486 | WP_000849566.1 | antirestriction protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 298 a.a. Molecular weight: 34298.40 Da Isoelectric Point: 5.9850
>T210906 WP_001114681.1 NZ_CP080120:c927917-927024 [Escherichia coli]
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGSTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGSTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN
Download Length: 894 bp
>T210906 NZ_CP104643:3987524-3987781 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCATCTTAAGGGCGACTGGCTGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAGCAGCTTTATCAGGCTAAACAGGTGGTTAAGGGAATT
AAGGACGTGCTGGTTTAG
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCATCTTAAGGGCGACTGGCTGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAGCAGCTTTATCAGGCTAAACAGGTGGTTAAGGGAATT
AAGGACGTGCTGGTTTAG
Antitoxin
Download Length: 132 a.a. Molecular weight: 14608.03 Da Isoelectric Point: 11.3150
>AT210906 WP_000208383.1 NZ_CP080120:c928305-927910 [Escherichia coli]
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRVLIVGKSKINA
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRVLIVGKSKINA
Download Length: 396 bp
>AT210906 NZ_CP104643:c3987699-3987367 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1X3JHM4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | V0YCI1 |