Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 92789..93624 Replicon chromosome
Accession NZ_CP080120
Organism Escherichia coli strain M24

Toxin (Protein)


Gene name yeeV Uniprot ID A0A376WVB1
Locus tag KZX72_RS00480 Protein ID WP_001094448.1
Coordinates 92789..93166 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3T7EC32
Locus tag KZX72_RS00485 Protein ID WP_024175935.1
Coordinates 93256..93624 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX72_RS00445 (87839) 87839..88843 - 1005 WP_001179707.1 IS110-like element ISSfl8 family transposase -
KZX72_RS00450 (88915) 88915..89475 - 561 Protein_90 DUF4942 domain-containing protein -
KZX72_RS00455 (89560) 89560..89752 - 193 Protein_91 hypothetical protein -
KZX72_RS00460 (89830) 89830..91443 - 1614 WP_000080195.1 IS66-like element ISEc23 family transposase -
KZX72_RS00465 (91474) 91474..91824 - 351 WP_000624722.1 IS66 family insertion sequence element accessory protein TnpB -
KZX72_RS00470 (91821) 91821..92246 - 426 WP_000422741.1 transposase -
KZX72_RS00475 (92328) 92328..92792 - 465 WP_061091426.1 DUF5983 family protein -
KZX72_RS00480 (92789) 92789..93166 - 378 WP_001094448.1 TA system toxin CbtA family protein Toxin
KZX72_RS00485 (93256) 93256..93624 - 369 WP_024175935.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KZX72_RS00490 (93698) 93698..93919 - 222 WP_000692346.1 DUF987 domain-containing protein -
KZX72_RS00495 (93988) 93988..94464 - 477 WP_001186709.1 RadC family protein -
KZX72_RS00500 (94476) 94476..94961 - 486 WP_000214415.1 antirestriction protein -
KZX72_RS00505 (95053) 95053..95871 - 819 WP_001234753.1 DUF932 domain-containing protein -
KZX72_RS00510 (95962) 95962..96195 - 234 WP_001117568.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14221.22 Da        Isoelectric Point: 8.2919

>T210902 WP_001094448.1 NZ_CP080120:c93166-92789 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T210902 NZ_CP104643:c1341104-1340577 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13598.40 Da        Isoelectric Point: 6.6255

>AT210902 WP_024175935.1 NZ_CP080120:c93624-93256 [Escherichia coli]
VSDTLSGTTHPDDNDDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT210902 NZ_CP104643:c1341391-1341101 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A376WVB1

Antitoxin

Source ID Structure
AlphaFold DB A0A3T7EC32

References