210900

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4565632..4566463 Replicon chromosome
Accession NZ_CP080119
Organism Escherichia coli strain M45

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag KZX76_RS22545 Protein ID WP_000854815.1
Coordinates 4566089..4566463 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag KZX76_RS22540 Protein ID WP_001280918.1
Coordinates 4565632..4566000 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX76_RS22495 (4560721) 4560721..4561467 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
KZX76_RS22500 (4561550) 4561550..4561900 + 351 Protein_4425 hypothetical protein -
KZX76_RS22505 (4561916) 4561916..4562326 + 411 WP_000846703.1 hypothetical protein -
KZX76_RS22510 (4562547) 4562547..4563365 + 819 WP_001542275.1 DUF932 domain-containing protein -
KZX76_RS22515 (4563365) 4563365..4563610 + 246 WP_001164966.1 hypothetical protein -
KZX76_RS22520 (4563704) 4563704..4564177 + 474 WP_001542276.1 antirestriction protein -
KZX76_RS22525 (4564193) 4564193..4564669 + 477 WP_001186200.1 RadC family protein -
KZX76_RS22530 (4564732) 4564732..4564953 + 222 WP_000692345.1 DUF987 domain-containing protein -
KZX76_RS22535 (4564972) 4564972..4565616 + 645 WP_000086752.1 hypothetical protein -
KZX76_RS22540 (4565632) 4565632..4566000 + 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KZX76_RS22545 (4566089) 4566089..4566463 + 375 WP_000854815.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
KZX76_RS22550 (4566460) 4566460..4566654 + 195 WP_000988600.1 DUF5983 family protein -
KZX76_RS22555 (4566700) 4566700..4566780 + 81 Protein_4436 hypothetical protein -
KZX76_RS25605 (4567069) 4567069..4567149 - 81 WP_023441679.1 hypothetical protein -
KZX76_RS25610 (4567128) 4567128..4567451 + 324 WP_225469267.1 EutP/PduV family microcompartment system protein -
KZX76_RS22570 (4567552) 4567552..4567881 - 330 WP_000450409.1 DUF496 family protein -
KZX76_RS22575 (4568053) 4568053..4569111 - 1059 WP_001200889.1 FUSC family protein -
KZX76_RS22580 (4569309) 4569309..4569782 - 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
KZX76_RS22585 (4569901) 4569901..4571067 - 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T210900 WP_000854815.1 NZ_CP080119:4566089-4566463 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T210900 NZ_CP104643:1177222-1177635 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT210900 WP_001280918.1 NZ_CP080119:4565632-4566000 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT210900 NZ_CP104643:1176975-1177241 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References