Detailed information of TA system TA021090

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 4617726..4618482
• Replicon: chromosome
• Accession: NC_006155
• Organism: Yersinia pseudotuberculosis IP 32953

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: A0A3G5KDU1
• Locus tag: YPTB_RS20890
• Protein ID: WP_032467110.1
• Coordinates: 4617726..4618094 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: Q664A5
• Locus tag: YPTB_RS20895
• Protein ID: WP_011193303.1
• Coordinates: 4618147..4618482 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YPTB_RS20860	4612818..4613825	+	1008	WP_011193296.1	iron chelate uptake ABC transporter family permease subunit	-
YPTB_RS20865	4613822..4614580	+	759	WP_011193297.1	ABC transporter ATP-binding protein	-
YPTB_RS20870	4614577..4615077	-	501	WP_002214364.1	virulence RhuM family protein	-
YPTB_RS20875	4615019..4615345	-	327	WP_011193298.1	hypothetical protein	-
YPTB_RS20880	4615368..4615775	-	408	WP_011193299.1	hypothetical protein	-
YPTB_RS23330	4616010..4616282	-	273	WP_011193300.1	Arm DNA-binding domain-containing protein	-
YPTB_RS20885	4616645..4617499	-	855	WP_032467109.1	DUF4942 domain-containing protein	-
YPTB_RS20890	4617726..4618094	-	369	WP_032467110.1	TA system toxin CbtA family protein	Toxin
YPTB_RS20895	4618147..4618482	-	336	WP_011193303.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
YPTB_RS20900	4618494..4618973	-	480	WP_011193304.1	hypothetical protein	-
YPTB_RS20905	4619156..4619776	-	621	WP_011193305.1	hypothetical protein	-
YPTB_RS20910	4619804..4620358	-	555	WP_011193306.1	hypothetical protein	-
YPTB_RS20915	4620606..4621232	-	627	WP_024063555.1	hypothetical protein	-
YPTB_RS20920	4621286..4621579	-	294	Protein_3953	ATP-binding protein	-
YPTB_RS20925	4622244..4622864	+	621	WP_011193309.1	inovirus Gp2 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (7-106)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13723.81 Da
• Isoelectric Point: 6.4530

>T21090 WP_032467110.1 NC_006155:c4618094-4617726 [Yersinia pseudotuberculosis IP 32953]
MQILPVTPKRAAYACPSPVVVWQSMLTYLLEQHYGLALNDTEFSDDAVIHEYIDAGISLSDALNFTVEKFGLVRIDRRGF
SCQEQSPFITAIDILRARRATGLMTRLGYQTIISVIRGEKQT

Nucleotide

• Length: 369 bp

>T21090 NC_006155:c4618094-4617726 [Yersinia pseudotuberculosis IP 32953]
ATGCAGATCTTACCTGTTACTCCGAAACGGGCGGCTTATGCTTGCCCATCACCCGTTGTTGTCTGGCAATCCATGCTCAC
GTATCTGCTGGAACAGCATTACGGATTGGCTCTTAACGATACCGAGTTCAGTGATGACGCCGTGATCCACGAATATATTG
ATGCTGGTATCTCTCTGTCCGATGCGTTGAATTTCACGGTGGAAAAGTTTGGCCTGGTTCGTATCGATCGCCGGGGGTTC
TCCTGCCAGGAACAATCTCCCTTCATCACGGCTATCGATATTCTCCGTGCCCGTCGAGCCACCGGCCTGATGACCCGTCT
GGGTTACCAGACCATCATCTCAGTTATCCGGGGCGAAAAGCAGACATGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12452.06 Da
• Isoelectric Point: 6.0555

>AT21090 WP_011193303.1 NC_006155:c4618482-4618147 [Yersinia pseudotuberculosis IP 32953]
MPSITTPAWGLKRNVTPQFGARLVQEGDRLHFLADRADINGTFSEVQVRDLDNAFPQFINYLELMLLSGELNPRHQHCVT
LYRNGLTCEADSLGSHGYVYLAIYPTPQSTA

Nucleotide

• Length: 336 bp

>AT21090 NC_006155:c4618482-4618147 [Yersinia pseudotuberculosis IP 32953]
ATGCCATCAATCACTACCCCAGCCTGGGGACTTAAACGCAACGTCACTCCGCAGTTTGGTGCCCGTCTGGTACAGGAAGG
CGACCGACTACATTTTCTAGCCGACCGTGCCGATATCAACGGAACCTTCAGCGAAGTGCAGGTACGTGATTTAGATAACG
CCTTCCCGCAGTTCATCAACTACCTGGAACTGATGCTGCTCTCCGGTGAGCTCAACCCTCGCCACCAGCACTGTGTCACG
TTGTATCGCAATGGCTTGACCTGTGAGGCCGATAGCCTGGGATCACACGGTTATGTGTATCTCGCTATTTATCCTACTCC
CCAATCAACTGCATAA

Structures

Toxin

• AlphaFold DB: A0A3G5KDU1

Antitoxin

• AlphaFold DB: Q664A5