Detailed information of TA system TA210891

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3982364..3983952
• Replicon: chromosome
• Accession: NZ_CP080119
• Organism: Escherichia coli strain M45

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A061YM43
• Locus tag: KZX76_RS19445
• Protein ID: WP_001125411.1
• Coordinates: 3982364..3983686 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A061YNW4
• Locus tag: KZX76_RS19450
• Protein ID: WP_001296076.1
• Coordinates: 3983686..3983952 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZX76_RS19435 (3979818)	3979818..3980528	-	711	WP_001195176.1	fimbria/pilus periplasmic chaperone	-
KZX76_RS19440 (3980890)	3980890..3981453	-	564	WP_001296074.1	type 1 fimbrial major subunit FimA	-
KZX76_RS19445 (3982364)	3982364..3983686	-	1323	WP_001125411.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
KZX76_RS19450 (3983686)	3983686..3983952	-	267	WP_001296076.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
KZX76_RS19455 (3984260)	3984260..3984634	+	375	WP_123312538.1	methyltransferase domain-containing protein	-
KZX76_RS19460 (3984638)	3984638..3985552	-	915	WP_001296077.1	bestrophin family protein	-
KZX76_RS19465 (3985749)	3985749..3987200	-	1452	WP_000854638.1	tagaturonate reductase	-
KZX76_RS19470 (3987427)	3987427..3988845	-	1419	WP_000558459.1	diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (7-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49329.96 Da
• Isoelectric Point: 7.7906

>T210891 WP_001125411.1 NZ_CP080119:c3983686-3982364 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAAEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHDRLSREYGIK

Nucleotide

• Length: 1323 bp

>T210891 NZ_CP104641:c4219132-4218641 [Salmonella enterica]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9987.34 Da
• Isoelectric Point: 4.9632

>AT210891 WP_001296076.1 NZ_CP080119:c3983952-3983686 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT210891 NZ_CP104641:c4219422-4219129 [Salmonella enterica]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Structures

Toxin

• AlphaFold DB: A0A061YM43

Antitoxin

• AlphaFold DB: A0A061YNW4