Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 2794213..2794831 | Replicon | chromosome |
Accession | NZ_CP080119 | ||
Organism | Escherichia coli strain M45 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | H5UYE2 |
Locus tag | KZX76_RS13395 | Protein ID | WP_001291435.1 |
Coordinates | 2794213..2794431 (-) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | S1PTH5 |
Locus tag | KZX76_RS13400 | Protein ID | WP_000344800.1 |
Coordinates | 2794457..2794831 (-) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KZX76_RS13360 (2789500) | 2789500..2790072 | + | 573 | WP_000779831.1 | YbaY family lipoprotein | - |
KZX76_RS13365 (2790103) | 2790103..2790414 | - | 312 | WP_000409908.1 | MGMT family protein | - |
KZX76_RS13375 (2790793) | 2790793..2791146 | + | 354 | WP_000878135.1 | DUF1428 family protein | - |
KZX76_RS13380 (2791188) | 2791188..2792738 | - | 1551 | WP_001385227.1 | cyclic-guanylate-specific phosphodiesterase PdeB | - |
KZX76_RS13385 (2792902) | 2792902..2793372 | - | 471 | WP_000136192.1 | YlaC family protein | - |
KZX76_RS13390 (2793488) | 2793488..2794039 | - | 552 | WP_000102539.1 | maltose O-acetyltransferase | - |
KZX76_RS13395 (2794213) | 2794213..2794431 | - | 219 | WP_001291435.1 | HHA domain-containing protein | Toxin |
KZX76_RS13400 (2794457) | 2794457..2794831 | - | 375 | WP_000344800.1 | Hha toxicity modulator TomB | Antitoxin |
KZX76_RS13405 (2795377) | 2795377..2798526 | - | 3150 | WP_001132478.1 | efflux RND transporter permease AcrB | - |
KZX76_RS13410 (2798549) | 2798549..2799742 | - | 1194 | WP_001295833.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T210885 WP_001291435.1 NZ_CP080119:c2794431-2794213 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T210885 NZ_CP104641:c2687176-2687073 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 125 a.a. Molecular weight: 14557.39 Da Isoelectric Point: 4.7395
>AT210885 WP_000344800.1 NZ_CP080119:c2794831-2794457 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
Download Length: 375 bp
>AT210885 NZ_CP104641:2687071-2687216 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 2MW2 | |
PDB | 1JW2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9QBQ5 |