Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2794213..2794831 Replicon chromosome
Accession NZ_CP080119
Organism Escherichia coli strain M45

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag KZX76_RS13395 Protein ID WP_001291435.1
Coordinates 2794213..2794431 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag KZX76_RS13400 Protein ID WP_000344800.1
Coordinates 2794457..2794831 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX76_RS13360 (2789500) 2789500..2790072 + 573 WP_000779831.1 YbaY family lipoprotein -
KZX76_RS13365 (2790103) 2790103..2790414 - 312 WP_000409908.1 MGMT family protein -
KZX76_RS13375 (2790793) 2790793..2791146 + 354 WP_000878135.1 DUF1428 family protein -
KZX76_RS13380 (2791188) 2791188..2792738 - 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
KZX76_RS13385 (2792902) 2792902..2793372 - 471 WP_000136192.1 YlaC family protein -
KZX76_RS13390 (2793488) 2793488..2794039 - 552 WP_000102539.1 maltose O-acetyltransferase -
KZX76_RS13395 (2794213) 2794213..2794431 - 219 WP_001291435.1 HHA domain-containing protein Toxin
KZX76_RS13400 (2794457) 2794457..2794831 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
KZX76_RS13405 (2795377) 2795377..2798526 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
KZX76_RS13410 (2798549) 2798549..2799742 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T210885 WP_001291435.1 NZ_CP080119:c2794431-2794213 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T210885 NZ_CP104641:c2687176-2687073 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT210885 WP_000344800.1 NZ_CP080119:c2794831-2794457 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT210885 NZ_CP104641:2687071-2687216 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References