Detailed information of TA system TA210884

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 2609835..2611524
• Replicon: chromosome
• Accession: NZ_CP080119
• Organism: Escherichia coli strain M45

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: KZX76_RS12540
• Protein ID: WP_000365807.1
• Coordinates: 2610604..2611524 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: KZX76_RS12535
• Protein ID: WP_001295795.1
• Coordinates: 2609835..2610617 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZX76_RS12530 (2606453)	2606453..2609551	-	3099	WP_000673070.1	type I restriction endonuclease	-
KZX76_RS12535 (2609835)	2609835..2610617	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
KZX76_RS12540 (2610604)	2610604..2611524	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
KZX76_RS25445 (2611689)	2611689..2612465	-	777	WP_000171155.1	site-specific integrase	-
KZX76_RS25450 (2612673)	2612673..2613008	-	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
KZX76_RS12550 (2613235)	2613235..2613393	-	159	Protein_2455	integrase	-
KZX76_RS12555 (2613442)	2613442..2613627	+	186	WP_000146240.1	hypothetical protein	-
KZX76_RS12560 (2613842)	2613842..2614456	+	615	WP_001019923.1	YagU family protein	-
KZX76_RS12565 (2614527)	2614527..2614693	+	167	Protein_2458	tail fiber assembly protein	-
KZX76_RS12570 (2614705)	2614705..2615034	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
KZX76_RS12575 (2615341)	2615341..2616051	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC	2603585..2651740	48155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T210884 WP_000365807.1 NZ_CP080119:2610604-2611524 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

>T210884 NZ_CP104641:c2437712-2437557 [Salmonella enterica]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT210884 WP_001295795.1 NZ_CP080119:2609835-2610617 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

>AT210884 NZ_CP104641:2437724-2437782 [Salmonella enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A061KTE0