210877

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1302105..1302940 Replicon chromosome
Accession NZ_CP080119
Organism Escherichia coli strain M45

Toxin (Protein)


Gene name yeeV Uniprot ID A0A376WVB1
Locus tag KZX76_RS06225 Protein ID WP_001094448.1
Coordinates 1302563..1302940 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3T7EC32
Locus tag KZX76_RS06220 Protein ID WP_024175935.1
Coordinates 1302105..1302473 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX76_RS06195 (1299303) 1299303..1299498 + 196 Protein_1217 DUF905 family protein -
KZX76_RS06200 (1299616) 1299616..1300434 + 819 WP_001234738.1 DUF932 domain-containing protein -
KZX76_RS06205 (1300776) 1300776..1301249 + 474 WP_001350782.1 antirestriction protein -
KZX76_RS06210 (1301265) 1301265..1301741 + 477 WP_001186771.1 RadC family protein -
KZX76_RS06215 (1301810) 1301810..1302031 + 222 WP_000692346.1 DUF987 domain-containing protein -
KZX76_RS06220 (1302105) 1302105..1302473 + 369 WP_024175935.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KZX76_RS06225 (1302563) 1302563..1302940 + 378 WP_001094448.1 TA system toxin CbtA family protein Toxin
KZX76_RS06230 (1302937) 1302937..1303425 + 489 WP_000761714.1 DUF5983 family protein -
KZX76_RS06235 (1303437) 1303437..1303629 + 193 Protein_1225 hypothetical protein -
KZX76_RS06240 (1303714) 1303714..1304559 + 846 WP_000065751.1 DUF4942 domain-containing protein -
KZX76_RS06245 (1305152) 1305152..1305649 + 498 WP_000509815.1 hypothetical protein -
KZX76_RS06250 (1305827) 1305827..1306750 + 924 WP_000535950.1 carboxylate/amino acid/amine transporter -
KZX76_RS06255 (1306754) 1306754..1307572 - 819 WP_000779409.1 lipoprotein NlpA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14221.22 Da        Isoelectric Point: 8.2919

>T210877 WP_001094448.1 NZ_CP080119:1302563-1302940 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T210877 NZ_CP104640:64977-65252 [Escherichia coli]
ATGGAACTGAAGTGGAGCAGTAAAGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13598.40 Da        Isoelectric Point: 6.6255

>AT210877 WP_024175935.1 NZ_CP080119:1302105-1302473 [Escherichia coli]
VSDTLSGTTHPDDNDDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT210877 NZ_CP104640:64693-64977 [Escherichia coli]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A376WVB1

Antitoxin

Source ID Structure
AlphaFold DB A0A3T7EC32

References