210873

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 464901..466182 Replicon chromosome
Accession NZ_CP080119
Organism Escherichia coli strain M45

Toxin (Protein)


Gene name sanaT Uniprot ID A0A1X3JHM4
Locus tag KZX76_RS02245 Protein ID WP_001114681.1
Coordinates 465289..466182 (+) Length 298 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID V0YCI1
Locus tag KZX76_RS02240 Protein ID WP_000208383.1
Coordinates 464901..465296 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX76_RS02195 (460395) 460395..460880 + 486 WP_000849566.1 antirestriction protein -
KZX76_RS02200 (460896) 460896..461372 + 477 WP_001186726.1 RadC family protein -
KZX76_RS02205 (461435) 461435..461656 + 222 WP_000692329.1 DUF987 domain-containing protein -
KZX76_RS02210 (461675) 461675..462319 + 645 WP_000094916.1 hypothetical protein -
KZX76_RS02215 (462369) 462369..462749 + 381 WP_001285598.1 type IV toxin-antitoxin system YeeU family antitoxin -
KZX76_RS02220 (462826) 462826..463203 + 378 WP_000854689.1 TA system toxin CbtA family protein -
KZX76_RS02225 (463200) 463200..463688 + 489 WP_000761699.1 DUF5983 family protein -
KZX76_RS02230 (463705) 463705..463902 + 198 WP_000839293.1 DUF957 domain-containing protein -
KZX76_RS02235 (463987) 463987..464832 + 846 WP_023281696.1 DUF4942 domain-containing protein -
KZX76_RS02240 (464901) 464901..465296 + 396 WP_000208383.1 DUF6088 family protein Antitoxin
KZX76_RS02245 (465289) 465289..466182 + 894 WP_001114681.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
KZX76_RS02250 (466653) 466653..466823 + 171 Protein_436 IS110 family transposase -
KZX76_RS02255 (467172) 467172..468671 + 1500 WP_000174401.1 IS21-like element ISEc10 family transposase -
KZX76_RS02260 (468668) 468668..469423 + 756 Protein_438 IS21-like element ISEc10 family helper ATPase IstB -
KZX76_RS02265 (470049) 470049..471032 + 984 WP_001296394.1 KpsF/GutQ family sugar-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(34-292)

Antitoxin

Protein of unknown function DUF6088

(10-129)


Sequences

Toxin        


Download         Length: 298 a.a.        Molecular weight: 34298.40 Da        Isoelectric Point: 5.9850

>T210873 WP_001114681.1 NZ_CP080119:465289-466182 [Escherichia coli]
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGSTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN

Download         Length: 894 bp

>T210873 NZ_CP104639:4859897-4860073 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14608.03 Da        Isoelectric Point: 11.3150

>AT210873 WP_000208383.1 NZ_CP080119:464901-465296 [Escherichia coli]
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRVLIVGKSKINA

Download         Length: 396 bp

>AT210873 NZ_CP104639:4860119-4860535 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAAGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCAGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3JHM4

Antitoxin

Source ID Structure
AlphaFold DB V0YCI1

References