210871

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 315257..315911 Replicon chromosome
Accession NZ_CP080119
Organism Escherichia coli strain M45

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag KZX76_RS01450 Protein ID WP_000244765.1
Coordinates 315257..315664 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag KZX76_RS01455 Protein ID WP_000354050.1
Coordinates 315645..315911 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX76_RS01430 (311214) 311214..312947 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
KZX76_RS01435 (312953) 312953..313663 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KZX76_RS01440 (313688) 313688..314584 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
KZX76_RS01445 (314696) 314696..315217 + 522 WP_001055874.1 flavodoxin FldB -
KZX76_RS01450 (315257) 315257..315664 - 408 WP_000244765.1 protein YgfX Toxin
KZX76_RS01455 (315645) 315645..315911 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
KZX76_RS01460 (316154) 316154..317134 + 981 WP_000886084.1 tRNA-modifying protein YgfZ -
KZX76_RS01465 (317211) 317211..317870 - 660 WP_000250275.1 hemolysin III family protein -
KZX76_RS01470 (318034) 318034..318345 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
KZX76_RS01475 (318390) 318390..319823 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T210871 WP_000244765.1 NZ_CP080119:c315664-315257 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T210871 NZ_CP104639:c4501152-4501045 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT210871 WP_000354050.1 NZ_CP080119:c315911-315645 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT210871 NZ_CP104639:4501200-4501259 [Escherichia coli]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References