Detailed information of TA system TA021087

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 2674736..2675719
• Replicon: chromosome
• Accession: NC_006155
• Organism: Yersinia pseudotuberculosis IP 32953

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q66A68
• Locus tag: YPTB_RS12340
• Protein ID: WP_011192520.1
• Coordinates: 2675261..2675719 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: YPTB_RS12335
• Protein ID: WP_002210982.1
• Coordinates: 2674736..2675182 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YPTB_RS12315	2670269..2670976	+	708	WP_038823925.1	murein tripeptide amidase MpaA	-
YPTB_RS12320	2671018..2671992	-	975	WP_002210985.1	L-Ala-D/L-Glu epimerase	-
YPTB_RS12325	2672155..2672658	+	504	WP_002210984.1	thiol peroxidase	-
YPTB_RS12330	2672822..2674399	-	1578	WP_011192519.1	transcriptional regulator TyrR	-
YPTB_RS12335	2674736..2675182	+	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
YPTB_RS12340	2675261..2675719	+	459	WP_011192520.1	RES family NAD+ phosphorylase	Toxin
YPTB_RS12345	2675729..2676790	-	1062	WP_002210980.1	YcjF family protein	-
YPTB_RS12350	2676787..2678184	-	1398	WP_002210979.1	YcjX family protein	-
YPTB_RS12355	2678165..2678407	-	243	WP_002216375.1	phage shock protein PspD	-
YPTB_RS12360	2678492..2678851	-	360	WP_002210977.1	envelope stress response membrane protein PspC	-
YPTB_RS12365	2678851..2679078	-	228	WP_002210976.1	envelope stress response membrane protein PspB	-
YPTB_RS12370	2679240..2679905	-	666	WP_011192521.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17008.41 Da
• Isoelectric Point: 4.8732

>T21087 WP_011192520.1 NC_006155:2675261-2675719 [Yersinia pseudotuberculosis IP 32953]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSLGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T21087 NC_006155:2675261-2675719 [Yersinia pseudotuberculosis IP 32953]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCTCATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGCTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT21087 WP_002210982.1 NC_006155:2674736-2675182 [Yersinia pseudotuberculosis IP 32953]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT21087 NC_006155:2674736-2675182 [Yersinia pseudotuberculosis IP 32953]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCTAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTATCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: Q66A68

Antitoxin

• AlphaFold DB: A0A0E8XFL1